Sebastian Joseph A., Strohm Eric M., Chérin Emmanuel, Mirani Bahram, Démoré Christine, Kolios Michael C., Simmons Craig A. High-frequency quantitative ultrasound for the assessment of the acoustic properties of engineered tissues in vitro. Acta Biomaterialia. 2022 | Elsevier
Eliathamby Daniella, Keshishi Melanie, Ouzounian Maral, Forbes Thomas L., Tan Kongteng, Simmons Craig A., Chung Jennifer. Ascending aortic geometry and its relationship to the biomechanical properties of aortic tissue. JTCVS Open. 2022. Elsevier
Bergevin Michele d., Boczula Anna E., Caruso Laura-lee., Persson Henrik., Simmons Craig A., Moriarty Tara J. A live cell imaging microfluidic model for studying extravasation of bloodborne bacterial pathogens. 2022. Cellular Microbiology. Wiley
Callaghan Neal I., Durland Lauren J., Ireland Ronald G., Santerre J. Paul, Simmons Craig A. Harnessing conserved signaling and metabolic pathways to enhance the maturation of functional engineered tissues. npj Regenerative Medicine. 2022 | Springer Nature
Congrats to Daniella on completing her BME MASc degree, co-supervised by Dr. Jennifer Chung and Craig!
Congratulations to Bahram for winning runner up in his panel for the 2022 Ted Rogers Trainee Day Poster Showcase!
Sefton Michael V, Simmons Craig A. Hearts by design. Science | AAAS
Congratulations to Bahram for receiving the Ontario Graduate Scholarship ($15,000)!
Dou Wenkun, Malhi Manpreet, Cui Teng, Wang Minyao, Wang Tiancong, Shan Guanqiao, Law Junhui, Gong Zheyuan, Plakhotnik Julia, Filleter Tobin, Li Renke, Simmons Craig A., Maynes Jason T., Sun Yu. A carbon-based biosensing platform for simultaneously measuring the contraction and electrophysiology of iPSC-cardiomyocyte monolayers. ACS Nano. 2022 | American Chemical Society
Wong Edwin KY., Parvin Nejad Shouka, D’Costa Katya A., Machado Siqueira Nataly, Lecce Monica, Santerre Paul, Simmons Craig A. Design of a mechanobioreactor to apply anisotropic, biaxial strain to large thin biomaterials for tissue engineered heart valve applications. Annals of Biomedical Engineering. 2022 | Springer
Nouri Shahrzad, Holcroft James, Caruso Laura-lee, Vuong Thu V., Simmons Craig A., Master Emma R., Ganss Berhnhard. An SCPPPQ1/LAM332 protein complex enhances the adhesion and migration of oral epithelial cells: Implications for dentogingival regeneration. 2022 | Elsevier.
Dou Wenkun, Malhi Manpreet, Zhao Qili, Wang Li, Huang Zongjie, Law Junhui, Liu Na, Simmons Craig A., Maynes Jason T., Sun Yu. Microengineered platforms for characterizing the contractile function of in vitro cardiac models. 2022 | Springer Nature
Persson Henrik, Park Siwan, Mohan Michael, Cheung Ka Kit, Simmons Craig A., Young Edmond WK. Rapid assembly of PMMA microfluidic devices with PETE membranes for studying the endothelium. Sensors and Actuators B: Chemical. 2021 | Elsevier
McClarty Davis, Ouzounian Maral, Tang Mingyi, Eliathamby Daniella, Romero David, Nguyen Elsie, Simmons Craig A., Amon Cristina, Chung Jennifer C-Y. Ascending aortic aneurysm haemodynamics are associated with aortic wall biomechanical properties. European Journal of Cardio-Thoracic Surgery. 2021 | Oxford Academic
Congratulations to Alisa for winning 1st prize for her poster at the CRAFT Virtual Symposium!
Anthonyshyn Jeremy A., Mazzoli Vienna, McFadden Meghan J., Gramolini Anthony O., Hofer Stefan O. P., Simmons Craig A., Santerre, Paul. Mitigating the non-specific uptake of immunomagnetic microparticles enables the extraction of endothelium from human fat. Communications Biology. 2021 | Nature Publishing Group
Congratulations to Neda for starting her NSERC Postdoctoral Fellowship this Fall!
Tang Mingyi, Eliathamby Daniella, Ouzounian Maral, Simmons Craig A, Chung Jennifer C.-Y. Dependency of energy loss on strain rate, strain magnitude and preload: Towards development of a novel biomarker for aortic aneurysm dissection risk. Journal of the Mechanical Behavior of Biomedical Materials. 2021 | Elsevier
Big congrats to Mingyi and Daniella for their paper just out in J Mech Behaviour of Biomed Materials!
Congratulations to Neda who was selected as the Student Board Member of the Canadian Biomaterials Society in June 2021!
Congratulations to Neda who was selected as a committee member of the Biomedical Engineering Society Diversity Committee in January 2021 for three years!
Liu Haijao, Usprech Jenna F., Parameshwar Prabu K., Sun Yu, Simmons Craig A. Combinatorial screen of dynamic mechanical stimuli for predictive control of MSC mechano-responsiveness. Science Advances. 2021 | AAAS
Mirani Bahram, Parvin Nejad Shouka, Simmons Craig A. Recent progress toward clinical translation of tissue engineered heart valves. Canadian Journal of Cardiology. 2021 | Elsevier
Congratulations to Monica who was awarded a NSERC Canada Graduate Scholarship Master’s!
Congratulations to Lily who was awarded a NSERC Canada Graduate Scholarship Doctoral!
Congratulations to Joseph who was awarded a NSERC Vanier Canada Graduate Scholarship!
Congratulations to Doris for passing her PhD qualifying exam!
Dou Wenkun, Wang Li, Malhi Manpreet, Liu Haijao, Zhao Qili, Plakhotnik Julia, Xu Zhensong, Huang Zongjie, Simmons Craig A., Maynes Jason T., Sun Yu. A microdevice platform for characterizing the effect of mechanical strain magnitudes on the maturation of iPSC-Cardiomyocytes. Biosensors and Bioelectronics. 2021 | Elsevier
Simmons Craig A., Ireland Ronald G. Stretch-boosted cell-mediation vascularization. Nature Biomedical Engineering. 2021 | Nature Publishing Group.
Congratulations to Neal for winning the Gordon Cressy Student Leadership Award that recognizes outstanding student leadership, service, and commitment to the University of Toronto!
Congratulations to Monica and Doris for being featured by the UofT Biomedical Engineering Student Association as role models for #WomenInScienceDay! All the women of the Simmons Lab inspire us as strong #WomenInScience.
Congratulations to Christian for passing his M.A.Sc. defense this past week!
Congratulations to Neda who was selected as part of the inaugural cohort of the Rising Stars in Engineering in Health on behalf of the Fu Foundation School of Engineering and Applied Science and the Vagelos College of Physicians and Surgeons at Columbia University!
Latifi Neda, Lecce Monica, Simmons Craig A. Porcine umbilical cord perivascular cells for preclinical testing of tissue engineered heart valves. Tissue Engineering Part C: Methods. 2020 | Mary Ann Liebert, Inc.
Maleki Hoda, Doyle Matthew G., Chehade Moussa, Liu Qian, Simmons Craig A. The focal mechanical properties of normal and diseased porcine aortic valve tissue measured by a novel microindentation device. Journal of the Mechanical Behavior of Biomedical Materials. 2020 | Elsevier.
Dou Wenkun, Wang Li, Malhi Manpreet, Liu Haijao, Zhao Qili, Plakhotnik Julia, Xu Zhensong, Huang Zongjie, Simmons Craig A., Maynes Jason T., Sun Yu. A microdevice platform for characterizing the effect of mechanical strain magnitudes on the maturation of iPSC-Cardiomyocytes. Biosensors and Bioelectronics. 2020 | Elsevier
Fitzsimmons Ross E.B., Ireland Ronald G., Zhong Aileen., Soos Agnes, Simmons Craig A., Assessment of fibrin-collagen co-gels for generating microvessels ex vivo using endothelial cell-lined microfluidics and multipotent stromal cell (MSC)-induced capillary morphogenesis. Biomedical Materials. 2020 | IOP Science.
Congratulations to Mingyi for passing her M.A.Sc. defense this past week!
Congratulations to Bahram for winning the UofT BME magazine cover competition with his beautiful scaffold SEM image: https://discover.bme.utoronto.ca/magazine-2020/ !
Congratulations to Joseph for passing his PhD qualifying exam!
Congratulations to Joseph (Oral) and Neal (Poster) who were awarded 1st places in the CRAFT 2020 Symposium today!
Congratulations to Neda on winning the Fonds de Recherche Nature et Technologies (FRQNT) Postdoctoral Scholarship for a second term starting this October 2020!
Chung Jennifer C-Y., Wong Edwin, Tang Mingyi, Eliathamby Daniella, Forbes Thomas L., Butany Jagdish, Simmons Craig A., Ouzounian Maral, Biomechanics of Aortic Dissection: A Comparison of Aortas Associated With Bicuspid and Tricuspid Aortic Valves. Journal of the American Heart Association. 2020 | Wiley
Callaghan Neal I., Lee Shin-Haw, Hadipour-Lakmehsari Sina, Lee Xavier A., Siraj M. Ahsan, Driouchi Amine, Yip Christopher M., Husain Mansoor,Simmons Craig A., Gramolini Anthony O., Functional culture and in vitro genetic and small-molecule manipulation of adult mouse cardiomyocytes. Communications Biology. 2020 | Nature Publishing Group
Ireland Ronald G., Kibschull Mark, Audet Julie, Ezzo Maya, Hinz Boris, Lye Stephen J., Simmons Craig A., Combinatorial extracellular matrix microarray identifies novel bioengineered substrates for xeno-free culture of human pluripotent stem cells. Biomaterials. 2020 | Elsevier
Miranda Maria Z., Turki Razan, Kuebler Wolfgang M., Simmons Craig A., Kapus Andras, Regulation of TAZ Expression by Cyclic Stretch. The FASEB Journal. 2020 | Wiley
Gellner Bryan, Xin Liming, Ribeiro Roberto V.P., Bissoondath Ved, Lu Pengzhoi, Adamson Mitchell B., Yu Frank, Paradiso Emanuela, Zu Jean, Simmons Craig A., Badiwala Mitesh V., The implementation of an adjustable afterload module during ex situ heart perfusion. Cardiovascular Engineering and Technology. 2020 | Springer
Gellner Bryan, Xin Liming, Ribeiro Roberto V.P., Bissoondath Ved, Adamson Mitchell B., Yu Frank, Lu Pengzhou, Paradiso Emanuela, Hondjeu Arnaud R.M., Simmons Craig A., Badiwala Mitesh V., The implementation of physiological afterload during ex situ heart perfusion augments prediction of posttransplant function. American Journal of Physiology – Heart and Circulatory Physiology. 2020 | American Physiological Society
Wong Jeremy F., Mohan Michael D., Young Edmond W.K., Simmons Craig A., Integrated electrochemical measurement of endothelial permeability in a 3D hydrogel-based microfluidic vascular model. Biosensors and Bioelectronics. 2020 | Elsevier
Hadipour-Lakmehsari Sina, Driouchi Amine, Lee Shin-Haw, Kuzmanov Uros, Callaghan Neal I., Heximer Scott P., Simmons Craig A., Yip Christopher M., Gramolini Anthony O., Nanoscale reorganization of sarcoplasmic reticulum in pressure-overload cardiac hypertrophy visualized by dSTORM. Scientific Reports. 2019 | Nature Publishing Group
Congratulations to Lauren Durland for receiving the highest scoring presentation in the “Human Health” category at UnERD 2020!
Congratulations to Bahram Mirani on receiving the Michael Smith Foreign Study Supplement to work on melt electrospinning of elastomeric scaffolds for heart valve tissue engineering!
Congratulations Joseph on receiving NSERC’s Alexander Graham Bell Canada Graduate Scholarship – Master’s.
Congratulations to Nataly on receiving the Canadian Biomaterials Society’s travel award to support travel to the 2020 World Biomaterials Congress in Glasgow later this year.
Congratulations to Bahram on receiving the Canadian Biomaterials Society’s travel award to support travel to the 2020 World Biomaterials Congress in Glasgow later this year.
Congratulations go out to Joseph who was selected to recieve a 2020 CRAFT Fellowship Award. The award is provided by the National Research Council of Canada (NRC) to help cover salary and research costs.
Congratulations Joseph, on receiving an award to attend the AIMBE Public Policy Institute in Washington, D.C.
Congratulations to Eric for winning best poster award at last week’s Ontario on a Chip conference.
This summer, Jenna will move to Vancouver to join University of British Columbia as Instructor in the School of Biomedical Engineering. A loss for us but a valuable gain for UBC. Congratulations Jenna!
Bailey was recently accepted to UofT Medical School and will be starting her new studies this fall. Congratulations Bailey!
Congratulations to Neal for winning best flash talk at this year’s TRCHR Heart Failure Symposium today.
Congratulations to Bahram who was just awarded a 3 year NSERC CGS-D scholarship.
Congratulations to Rachel on winning the 2018-2019 “Lorne Phenix Graduate Award” from the Cardiovascular Sciences Collaborative Specialization (CSCS)! This award is given on the basis of research and academic excellence for cardiovascular research related to women.
Callaghan Neal, Hadipour-Lakmehsari Sina, Lee Shin-Haw, Gramolini Anthony O., Simmons Craig A., Modeling cardiac complexity: Advancements in myocardial models and analytical techniques for physiological investigation and therapeutic development in vitro. APL Bioengineering. 2019 | AIP
Wong Jeremy, Simmons Craig A. Microfluidic assay for the on-chip electrochemical measurement of cell monolayer permeability. Lab on a chip. 2019 | RSC
Congratulations Neda on recieving First Rank in the Multidisciplinary Committee of the Fonds de Recherche du Quebec-Nature et Technologies Postdoctoral Fellowship Award.
Congratulations to Bahram for being awarded the 6T6 Industrial Engineering 50th Fellowship in Healthcare Engineering.
Congratulations to Alan on winning the Cardiovascular Sciences Collaborative Specialization Travel Award to cover his expenses for the 8th Biennial Heart Valve Biology & Tissue Engineering Meeting in London, England.
Lam Alan Y, Simmons Craig A., Cell and Extracellular Matrix Interactions in a Dynamic Biomechanical Environment: The Aortic Valve as an Illustrative Example. In: Labrosse MR, eds. Cardiovascular Mechanics. Boca Raton, FL: CRC Press; 2018. | Book Chapter
Fitzsimmons Ross E. B, Mazurek Matthew S, Soos Agnes, Simmons Craig A. Mesenchymal Stromal/Stem Cells in Regenerative Medicine and Tissue Engineering. Stem Cells International. 2018 | Hindawi
Congratulations to Bailey who was awarded the Canadian Centennial Scholarship from the Alpha Phi Foundation for 2018-2019.
Fitzsimmons Ross EB, Aquilino Mark S., Quigley Jasmine, Chebotarev Oleg, Tarlan Farhang, Simmons Craig A. Generating vascular channels within hydrogel constructs using an economical open-source 3D bioprinter and thermoreversible gels. Bioprinting: 2018; 9:7-18 | ScienceDirect
Liu Haijiao, MacQueen Luke A., Usprech Jenna F., Maleki Hoda, Sider Krista L., Doyle Matthew G., Sun Yu, Simmons Craig A. Microdevice arrays with strain sensors for 3D mechanical stimulation and monitoring of engineered tissues. Biomaterials. 2018;172:30-40 |ScienceDirect
Zhong, Aileen, Mirzaei, Zahra, Simmons, Craig A. The Roles of Matrix Stiffness and ß-Catenin Signaling in Endothelial-to- Mesenchymal Transition of Aortic Valve Endothelial Cells. Cardiovascular Engineering and Technology. 2018;9:158-167|Springer
Congratulations Agnes, to receiving the award for best poster in the category Biomaterials, Tissue Engineering and Regenerative Medicine at IBBME’s annual research conference, iARC 2018. For more info on the event and to see the other winners, follow this link.
Congratulations Craig! During the past weekend, Craig was elected a Fellow of the American Institute for Medical and Biological Engineering (AIMBE), an honor awarded few in the field.
Last week, a delegation from Canadian Institutes for Health Research (CIHR) visited our department (TBEP, Translational Biology and Engineering Program). The visit served as a public announcement for the 2017 CIHR grants (awarded April last year), 10 of which went to UofT and 4 to TBEP, including the Simmons lab for Engineering Pulmonary Valve Tissue for Pediatric Patients with Tetralogy of Fallot and Development of a physiological cardiac microtissue platform for drug development.
Blaser MC, Wei K, Adams RLE, Zhou YQ, Caruso LL, Mirzaei Z, Lam AY, Tam RKK, Zhang H, Heximer SP, Henkelman RM, Simmons CA. Deficiency of Natriuretic Peptide Receptor 2 Promotes Bicuspid Aortic Valves, Aortic Valve Disease, Left Ventricular Dysfunction, and Ascending Aortic Dilatations in Mice. Circulation Research. 2018; 2(122): 405-416 | PubMed
Bailey, Shouka, and Craig described the lab’s research in heart valve disease and heart valve tissue engineering to Heart and Stroke Foundation canvassers and other volunteers at the Bowmanville Heart Rally.
At the 2017 Ontario Professional Engineers Awards, Craig was awarded the Engineering Medal for Research and Development. This medal is awarded “for using new knowledge in developing useful, novel applications, or advancing engineering knowledge or applied science, or discovering or extending any of the engineering or natural sciences.”
Wong F. Jeremy, Young Edmond W.K, Simmons, Craig A. Computational analysis of integrated biosensing and shear flow in a microfluidic vascular model. AIP Advances. 2017; 7: 115116 | AIP
A desicription of Shouka’s research into child friendly heart valves is featured at Ted Roger’s Center for Heart Research. The piece is written by Agnes.
She was born with heart defects. Now she’s researching a cure. Bailey recently joined the Simmons lab as a grad student at IBBME who chose to write a piece about her story and her choice in going into heart research. Read more over at IBBME.
Zhang Xiaoqing, Battiston Kyle, Simmons Craig A, Santerre J Paul. Differential regulation of extracellular matrix components by using different vitamin C derivatives in mono-and co-culture systems. ACS Biomaterials Science & Engineering. 2017 | ACS
Leung General, Kirpalani Anish, Szeto Stephen G, Deeb Maya, Warren Foltz, Simmons Craig A, Yuen Darren A. Could MRI Be Used To Image Kidney Fibrosis? A Review of Recent Advances and Remaining Barriers. Clinical Journal of the American Society of Nephrology. 2017;12(6):1019-1028 | PubMed
Zhang Xiaoqing, Battiston Kyle G, Labow Rosalind S, Simmons Craig A,Santerre J Paul. Generating favorable growth factor and protease release profiles to enable extracellular matrix accumulation within an in vitro tissue engineering environment. Acta Biomaterialia. 2017;54:81-84 | PubMed
Wen Jun, Tao Hirotaka, Lau Kimberly, Liu Haijiao, Simmons Craig A, Sun Yu, Hopyan Sevan. Cell and Tissue Scale Forces Coregulate Fgfr2-Dependent Tetrads and Rosettes in the Mouse Embryo. Biophysical Journal. 2017;112(10):2209-2218. | PubMed
Zhang Xiaoqing, Bendeck Michelle P, Simmons Craig A, Santerre, J Paul. Deriving vascular smooth muscle cells from mesenchymal stromal cells: Evolving differentiation strategies and current understanding of their mechanisms. Biomaterials; 2017;145:9-22 | PubMed
Safaee Helia, Bakooshli Mohsen A, Davoudi Sadegh, Cheng, Richard Y, Martowirogo Aditya J, Li Edward W, Simmons Craig A, Gilbert, Penney M. Tethered Jagged-1 Synergizes with Culture Substrate Stiffness to Modulate Notch-Induced Myogenic Progenitor Differentiation. Cellular and molecular bioengineering. 2017;10(5):501-513. | SpringerLink
Usprech Jenna, Romero David A, Amon Cristina H, Simmons Craig A. Combinatorial screening of 3D biomaterial properties that promote myofibrogenesis for mesenchymal stromal cell-based heart valve tissue engineering. Acta Biomaterialia. 2017;58:34-43. | PubMed
Ethier CR, Simmons CA. Biomechanics: From cells to organisms. Cambridge University Press, New York, 2007. | Textbook
Sun Y, Kim D-H, Simmons CA. (eds.) Integrative Mechanobiology: Micro and Nano Techniques in Cell Mechanobiology. Cambridge University Press, 2015. | Edited Book
Zhong A, Simmons CA. Heart valve mechanobiology in development and disease. In: Chien S, Engler AJ, Wang Y (eds.) Molecular and Cellular Mechanobiology. American Physiological Society, 2016. | Book Chapter
Moraes C*, MacQueen LA*, Sun Y, Simmons CA. Microscale generation of dynamic forces in cell culture systems. In: Sun Y, Kim D-H, Simmons CA. (eds.) Integrative Mechanobiology: Micro and Nano Techniques in Cell Mechanobiology. Cambridge University Press, 2015. | Book Chapter
Battiston KG, Santerre JP, Simmons CA. Mechanobiological stimulation of engineered vascular tissues. In: Sun Y, Kim D-H, Simmons CA. (eds.) Integrative Mechanobiology: Micro and Nano Techniques in Cell Mechanobiology. Cambridge University Press, 2015. | Book Chapter
Blaser MC, Simmons CA. Mechanical and matrix regulation of fibrosis. In: Dixon IAC and Wigle J (eds.), Mechanisms of Cardiac Fibrosis and Heart Failure. Springer, 2015. | Book Chapter
Srigunapalan S, Simmons CA. Valvular endothelial mechanobiology. In: Aranda-Espinoza H (ed.), Mechanobiology of the Endothelium. CRC Press, 2015. | Book Chapter
MacQueen L, Moraes C, Sun Y, Simmons CA. Dynamic mechanical environments to quantify and control cellular dynamics. In: Cuerrier CM, Pelling AE (eds), Cells, Forces, and the Microenvironment. Pan Stanford Publishing, 2015. | Book Chapter
Blaser M, Simmons CA. Mechanobiology of cardiac and valvular fibrosis. In: Layton B (ed.), Molecular and Cellular Biomechanics. Pan Stanford Publishing, 2015. | Book Chapter
Liu J*, Moraes C*, Lu Z, Simmons CA, Sun Y. Single cell deposition. In: Methods Cell Biol, 2012: 112:403-420. | Book Chapter
Moraes C, Sun Y, Simmons CA. Micro and nano-technologies for studies in cellular mechanics and mechanobiology. In: Gefen A (ed.), Cellular and Biomolecular Mechanics and Mechanobiology. Springer-Verlag, 2011. | Book Chapter
Chen WLK, Simmons CA. Mesenchymal stem cell mechanobiology. In: Nagatomi J (ed.), Mechanobiology Handbook. CRC Press, Boca Raton, 2011. | Book Chapter
Yip YYC*, Chen JH*, Simmons CA. Engineering substrate mechanics to regulate cell response. In: Khademhosseini et al. (eds.) Micro- and Nanoengineering of the Cell Microenvironment: Technologies and Applications. Artech House Publishing Inc., 2008. | Book Chapter
Simmons CA, Mooney DJ. Regulation of cellular response to mechanical signals by matrix design. In: Guilak, F. et al. (eds.) Functional Tissue Engineering. Springer-Verlag, Inc., New York, 2003. | Book Chapter
Pilliar RM, Simmons CA. Mechanical factors and osseointegration: Influence of implant design. In: Zarb, G. et al. (eds.) Aging, Osteoporosis and Dental Implants. Quintessence, Chicago, 2001. | Book chapter
Simmons CA, Pilliar RM. A biomechanical study of early tissue formation around bone-interfacing implants – The effect of implant surface geometry, In: Davies, J.E. (ed.) Bone Engineering. em squared, Inc., Toronto, 2001 | Book Chapter
Congratulations to Agnes who was awarded the Stem Cell Network International Travel Award, 2017.
Congratulations to Agnes who was awarded the Wildcat Voyager Fellowship, 2017.
Congratulations to Agnes who was awarded the NSERC CREATE TOeP scholarship (Training Program in Organ-on-a-Chip Engineering and Entrepreneurship), 2016.
Congratulations to Agnes who was awarded the NSERC CREATE MATCH scholarship Microfluidic Applications & Training in Cardiovascular Health) in 2015.
Wong Jeremy F., Simmons Craig A., Young Edward W.K. Modeling and Measurement of Biomolecular Transport and Sensing in Microfluidic Cell Culture and Analysis Systems, In: Becker, S. (ed.) Model. Microscale Transp. Biol. Process. 1st ed. 2017; Elsevier, pp. 41–75. | Book Chapter
Ebady R, Niddam AF, Boczula AE, Kim YR, Gupta N, Tang TT, Odisho T, Zhi H, Simmons CA, Skare JT, Moriarty TJ. Biomechanics of Borrelia burgdorferi vascular interactions. Cell Rep. 2016;16(10):2593-604. | PubMed
Loai S, Haedicke I, Mirzaei Z, Simmons CA, Zhang XA, Cheng HL. Positive-contrast cellular MRI of embryonic stem cells for tissue regeneration using a highly efficient T1 MRI contrast agent. J Magn Reson Imaging, 2016; 44:1456-1463| PubMed
Usprech J, Chen WLK, Simmons CA. Heart valve regeneration: The need for systems approaches. WIRE Systems Biology and Medicine, 2016; 8:169-82. | PubMed
Liu Haijiao, Usprech Jenna, Sun Yu, Simmons Craig A. A microfabricated platform with hydrogel arrays for 3D mechanical stimulation of cells. Acta Biomaterialia, 2016; 34:113-24. | PubMed
Parvin Nejad S, Blaser MC, Santerre JPS, Caldarone CA, Simmons CA. Biomechanical conditioning of tissue engineered heart valves: Too much of a good thing? Advanced Drug Delivery Reviews, 2016;96:161-75. | PubMed
Ireland R, Simmons CA. Pluripotent stem cell mechanobiology. Stem Cells (invited review), 2015;33:3187-96. | PubMed
Niu CJ, Fisher C, Scheffler K, Wana R, Maleki H, Liu H, Sun Y, Simmons CA, Birngruber R, Lilge L. Polyacrylamide gel substrates that simulate the mechanical stiffness of normal and malignant neuronal tissues increase protoporphyin IX synthesis in glioma cells. Journal of Biomedical Optics, 2015;20:98002. | PubMed
Kheradvar A, Groves EM, Falahatpisheh A, Mofrad MK, Alavi SH, Tranquillo R, Dasi LP, Simmons CA, Grande-Allen KJ, Goergen CJ, Baaijens F, Little SH, Canic S, Griffith B. Emerging trends in heart valve engineering: Part IV. Computational modeling and experimental studies. Ann Biomed Eng, 2015;43:2314-33. | PubMed
Plaza GR, Uyeda TQP, Mirzaei Z, Simmons CA. Study of the influence of actin-binding proteins using linear analyses of cell deformability. Soft Matter, 2015;11:5435-46. | PubMed
Battiston KG, Ouyang B, Honarparvar E, Qian J, Labow RS, Simmons CA, Santerre JP. Interaction of a block-co-polymeric biomaterial with immunoglobulin G modulates human monocytes towards a non-inflammatory phenotype. Acta Biomaterialia, 2015; 24:35-43. | PubMed
Battiston KG, Labow RS, Simmons CA, Santerre JP. Immunomodulatory polymeric scaffold enhances extracellular matrix production in cell co-cultures under dynamic mechanical stimulation. Acta Biomaterialia, 2015;24:74-86. | PubMed
Lau K, Tao H, Liu H, Wen J, Sturgeon K, Sorfazlian N, Lazic S, Burrows JTA, Wong M, Li D, Deimling S, Ciruna B, Scott I, Simmons CA, Henkelman RM, Williams T, Hadjantonakis AK, Fernandez-Gonzalez R, Sun Y, Hopyan S. Anisotropic stress orients remodelling of mammalian limb bud ectoderm. Nat Cell Biol, 2015;17:569–579. | PubMed
Kheradvar A, Groves EM, Dasi LP, Alavi SH, Tranquillo RT, Grande-Allen KJ, Simmons CA, Griffith BE, Falahatpisheh A, Goergen CJ, Mofrad MRK, Baaijens FPT, Little SH, Canic S. Emerging trends in heart valve engineering: Part I. Solutions for the future. Ann Biomed Eng, 2015;43:833-43. | PubMed
Kheradvar A, Groves EM, Goergen CJ, Alavi SH, Tranquillo RT, Simmons CA, Dasi LP, Grande-Allen KJ, Mofrad MRK, Falahatpisheh A, Griffith BE, Baaijens FPT, Little SH, Canic S. Emerging trends in heart valve engineering: Part II. Novel and standard technologies for aortic valve replacement. Ann Biomed Eng, 2015;43:844-57. | PubMed
Kheradvar A, Groves EM, Simmons CA, Griffith BE, Hamed Alavi S, Tranquillo RT, Dasi LP, Falahatpisheh A, Grande-Allen KJ, Goergen CJ, Mofrad MRK, Baaijens FPT, Canic S, Little SH. Emerging trends in heart valve engineering: Part III. Novel technologies for mitral valve repair and replacement. Ann Biomed Eng, 2015;43:858-70. | PubMed
Mohammadi H, Arora PD, Simmons CA, Janmey PA, McCulloch CA. Inelastic behaviour of collagen networks in cell-matrix interactions and mechanosensation. J R Soc Interface, 2015;12:20141074 | PubMed
Congratulations to Henrik for securing funding for a 3 year International Postdoc grant from the Swedish Research Council.
Major congratulations to Craig who has been appointed University of Toronto Distinguished Professor of Mechanobiology by the University of Toronto Office of the Vice-President and Provost for his exceptional career accomplishments and promise, his excellence in research, education and leadership!
Please join us to congratulate Craig on this well-deserved distinction!
Congratulations to Haijiao Liu who wins a Canadian Biomaterials Society (CBS) Travel Award of $500 based on his top-scoring abstract!
Craig provides some insights into an auspicious first year of interdisciplinary collaboration between U of T and the Ted Rogers Centre for Heart Research. Read the full article on U of T Engineering News here.
Congratulations to Craig who was awarded the 2015 CP Has Heart Cardiovascular Award from the Heart and Stroke Foundation and Canadian Pacific! Craig is one of 10 researchers to be selected among 454 grant applications from across Canada and awarded a total of $3 million over three years to support his innovative research in finding a treatment for diseased heart valves.
Congratulations to Jenna who was selected by TERMIS SYIS-AM to receive a travel award for Women in TERM!
Congratulations to Craig who has been appointed Scientific Director of Translational Biology and Engineering Program (TBEP), effective July 1, 2015! Click here to read the full story in U of T Engineering News.
Congratulations to Craig and his research team who have been awarded a grant to create a 3D model of the human liver. Funded by Ontario Centres of Excellence and pharmaceutical consortium CQDM, the research project could help test the safety of new drug molecules and therefore, speed up the approval process of new drugs.
Congratulations to Mark who won the NAVBO Trainee Travel Award to Vascular Biology Gordon Research Conferences (two awarded biennially across North America by
the conference chairs)!
Congratulations to Mark who won Best Podium Presentation Award, IBBME Scientific Day 2015!
Congratulations to Agnes, who was awarded a Frank and Barbara Milligan Graduate Fellowship for 2014-15.
Battiston KG, Ouyang B, Labow RS, Simmons CA, Santerre JP. Using monocytes/macrophages and their cytokine activity to promote vascular smooth muscle cell growth on a degradable polyurethane scaffold. Acta Biomaterialia, 2014;10:1146-55. | PubMed
Congratulations to Richard, who successfully defended his MASc thesis today!
Jenna thoroughly impressed Cheryl Regehr, Vice President & Provost of the University of Toronto by leading her on a tour of the lab and describing her work in identifying environmental conditions that enable bone marrow MSCs to develop tissue that could act as a functional, regenerative replacement for diseased heart valves.
Sider KL, Zhu C, Kwong AV, Mirzaei Z, De Lange CFM, Simmons CA. Evaluation of a porcine model of early aortic valve sclerosis. Cardiovasc Pathol, 2014;23:289-97.| PubMed
Congratulations to Jessica, who won 2nd place in the World Congress of Biomechanics Student Paper Competition in the Fluid Mechanics, Biotransport, and Tissue/Cellular Engineering Category on July 8, 2014!
Aleks and his “tissue-on-a-chip” microfluidic platform are featured in a story on the Techno incubator program at the University of Toronto.
Congratulations to Michele, who won third prize at the Microbiology & Infectious Diseases Research Day 2014 for her poster entitled “Development of a Microfluidic Transmembrane Flow System to Characterize the Role of Chemotaxis and Motility in Borrelia burgdorferi Extravasation.”
|Congratulations to David, who was awarded an Ontario Graduate Scholarship for 2014-15!|
|Congratulations to Jenna, who was awarded an Ontario Graduate Scholarship for 2014-15!|
|Congratulations to Andrea, who successfully defended her MASc thesis today!|
|Congratulations to Craig, who was appointed as Associate Director, Research of the Institute of Biomaterials & Biomedical Engineering (IBBME) for a term of three years beginning July 1, 2014. This appointment follows his one year in the position as an acting associate director.|
|Congratulations to Craig, who was elected as a Fellow of the Canadian Society of Mechanical Engineers for excellence in mechanical engineering and active contribution to the progress of the profession and of the society.|
Congratulations to Team Heart Valve, who completed the 50-km Becel Heart & Stroke Ride for Heart on June 1. The team, comprised of 17 lab members and friends, raised $5200 for the Heart & Stroke Foundation. This amount is the most we’ve ever raised in the 7 years we’ve participated as a lab team. Thanks to all of our generous sponsors!
|Congratulations to Krista, Andrea, and Zahra, whose paper “Evaluation of a porcine model of early aortic valve sclerosis” was accepted for publication in Cardiovascular Pathology.|
|Congratulations to Michele, who won the CMC Microsystems Best Poster Award in the Engineering and Physical Sciences category at the Ontario-on-a-Chip/MATCH Symposium.|
|Alex was awarded a Heffernan Commercialization Fellowship, a program that awards promising inventors with $32,000 to develop their products into viable businesses. More details about the fellowship are available here.|
|Congratulations to Craig on his promotion to full Professor! Your lab is extremely proud of you! 🙂|
|Congratulations to our undergraduate research students who received scholarships for the summer. Jessica received a CIHR Institute of Musculoskeletal Health and Arthritis Studentship and Mark received a Dental Research Institute Summer Research Program Award. Congratulations to both!|
Liu H, Wen J, Xiao Y, Liu J, Hopyan S, Radisic M, Simmons CA#, Sun Y#. In situ mechanical characterization of the cell nucleus by atomic force microscopy. ACS Nano, 2014;8:3821-8.| PubMed
|Mark Blaser has been selected as the 2013-2014 “Lorne Phenix Graduate Award” recipient by the Cardiovascular Sciences Collaborative Program, Faculty of Medicine, University of Toronto. This award is made possible by a generous donation in the memory of Mr. Lorne Phenix by the Phenix family. It is given on the basis of research and academic excellence and consists of a cash prize and a certificate.|
Congratulations to Haijiao, whose paper “In situ mechanical characterization of the cell nucleus by atomic force microscopy” was published in ACS Nano.
Xiao Y, Zhang B, Liu H, Miklas JW, Gagliardi M, Pahnke A, Thavandiran N, Sun Y, Simmons CA, Keller G, Radisic M. Microfabricated perfusable cardiac biowire: a platform that mimics native cardiac bundle. Lab Chip, 2014;14:869-82. | Pubmed
Liu H, Tan Q, Geddie WR, Jewett MAS, Phillips N, Ke D, Simmons CA, Sun Y. Biophysical characterization of bladder cancer cells with different metastatic potential. Cell Biochem Biophys, 2014; 68:241-97.| PubMed
Battiston KG, Ouyang B, Labow RS, Simmons CA, Santerre JP. Using monocytes/macrophages and their cytokine activity to promote vascular smooth muscle cell growth on a degradable polyurethane scaffold. Acta Biomaterialia, 2014;10:1146-55.| PubMed
|Congratulations to Ronnie, who received a CIHR Canada Graduate Scholarship – Master’s for 2014-15.|
|Congratulations to Noam, who successfully defended his MASc thesis today!|
Thavandiran N, Dubois N, Mikryukov A, Masse S, Beca B, Simmons CA, Deshpande V, McGarry P, Chen CS, Nanthakumar K, Keller G, Radisic M, Zandstra PW. Design and formulation of functional pluripotent stem cell-derived cardiac microtissues. Proc Natl Acad Sci U S A, 2013;110:E4698-707.| PubMed
Zhao R, Simmons CA. A simple method to estimate the exponential material parameters of heart valve tissue based on analogy between uniaxial tension and micropipette aspiration. Biomech Model Mechanobiol, 2013;12:1283-90.| PubMed
|Congratulations to Agnes, who received two awards from IBBME for 2013-14: the Wildcat Graduate Scholarship for outstanding academic achievement and extra-curricular leadership, and the Anna Jamieson award for her leadership and contributions to the quality of life in IBBME.|
Heckler AF, Mirzaei Z, Pereira I, Simmons CA, Gong S-G. Development of a three-dimensional in vitro model system to study orthodontic tooth movement. Arch Oral Biol, 2013;58:1498-1510.| PubMed
|Congratulations to Justin, who successfully defended his MASc thesis today!|
|Congratulations to Suthan, who successfully defended his Ph.D. thesis today!|
Liu H, Sun Y, Simmons CA. Determination of local and global elastic moduli of valve interstitial cells cultured on soft substrates. J Biomech, 2013;46:1967-71.| PubMed
|Congratulations to Michele, who received a Heart & Stroke/Richard Lewar Center of Excellence Studentship award for 2013-14.|
Chen MB, Srigunapalan S, Wheeler AR, Simmons CA. A 3D microfluidic platform incorporating methacrylated gelatin hydrogels to study physiological cardiovascular cell–cell interactions. Lab Chip, 2013;13:2591-8.| PubMed
Gould ST, Srigunapalan S, Simmons CA, Anseth KS. Hemodynamic and cellular response feedback in calcific aortic valve disease. Circ Res, 2013;113:186-97.| PubMed
|Congratulations to Kelly, who successfully defended her Ph.D. thesis today!|
|Congratulations to Ronnie, who was awarded an Ontario Graduate Scholarship for 2013-14!|
|Congratulations to Jeremy, who was awarded a Queen Elizabeth II Graduate Scholarship for 2013-14!|
|Congratulations to Haijiao, whose paper “Determination of local and global elastic moduli of valve interstitial cells cultured on soft substrates” was accepted for publication in Journal of Biomechanics.|
|Congratulations to Mike, who was awarded an Ontario Graduate Scholarship for 2013-14!|
|Congratulations to Noam, who was awarded a SGS Conference Grant to present his work at a conference this summer.|
|Congratulations to our new group of undergraduate research students who received scholarships for the summer. Linda received an NSERCUndergraduate Student Research Award, Jessica received a CIHR Institute of Musculoskeletal Health and Arthritis Studentship, Kathak received a Dental Research Institute Summer Research Program Award, and Aileen received a University of Toronto Undergraduate Research Opportunity Award. Congratulations to all!|
Macqueen L, Sun Y, Simmons CA. Mesenchymal stem cell mechanobiology and emerging experimental platforms. J R Soc Interface, 2013;10:20130179.| PubMed
Congratulations to Ross, who was awarded a 3-year CIHR Frederick Banting and Charles Best Canada Graduate Scholarship (CGS) Doctoral Award!
Congratulations to Luke, whose paper “Mesenchymal stem cell mechanobiology and emerging experimental platforms” was accepted for publication in Journal of the Royal Society Interface.
Moraes C*, Likhitpanichkul M*, Lam CJ, Beca BM, Sun Y, Simmons CA. Microdevice array-based identification of distinct mechanobiological response profiles in layer-specific valve interstitial cells. Integr Biol, 2013;5:673-80.| PubMed
|Congrats to Michelle and Suthan, whose paper “A 3D microfluidic platform incorporating methacrylated gelatin hydrogels to study physiological cardiovascular cell–cell interactions” was accepted for publication in Lab on a Chip.|
Congrats to Chris, Morakot, and Bogdan, whose paper “Microdevice array-based identification of distinct mechanobiological response profiles in layer-specific valve interstitial cells” was accepted for publication in Integrated Biology.
Congratulations to Ruogang whose paper “A simple method to estimate the exponential material parameters of heart valve tissue based on analogy between uniaxial tension and micropipette aspiration” was published in Biomechanics and Modeling in Mechanobiology.
Congrats to Noam, who received an NSERC Microfluidics Applications and Training in Cardiovascular Health (MATCH) Travel Award!
Congratulations to Mike, Haijiao, and Richard on being awarded Barbara and Frank Milligan Graduate Fellowships for 2012-13.
MacQueen L, Chebotarev O, Simmons CA#, Sun Y#. Miniaturized platform with on-chip strain sensors for compression testing of arrayed materials. Lab Chip, 2012;12:4178-84.| PubMed
Al-Haque S, Miklas JW, Feric N, Chiu LL, Chen WL, Simmons CA, Radisic M. Hydrogel substrate stiffness and topography interact to induce contact guidance in cardiac fibroblasts. Macromol Biosci, 2012;12:1342-53.| PubMed
Congratulations to lab alumnus, Chris Moraes, who is the recipient of a two-year Banting Postdoctoral Fellowship. The Banting Postdoctoral Fellowships are Canada’s most prestigious awards for postdoctoral fellows. Only 70 fellowships are awarded annually across all three federal granting agencies. Chris won one of only 26 awarded by NSERC. More details are available here: http://news.gc.ca/web/article-eng.do?nid=695009
Congratulations to Kathak, who won the Omicron Kappa Upsilon Tau Tau Chapter Award for 2nd place in the Faculty of Dentistry Summer Research Presentation competition. Kathak will receive $1200 to cover expenses for a conference.
Congratulations to Kathak who was runner up in her session of the Canadian Society for Chemical Engineering Symposium held in conjunction with UnERD 2012. Kathak’s research project, done under the supervision of Mark, was titled “Characterising Apolipoprotein A1 in Early Aortic Valve Disease in Mice”
Congratulations to Craig, who was named a recipient of a prestigious McLean Award, part of the Connaught Fund. The award honours emerging leaders in basic research in the fields of physics, chemistry, computer science, mathematics, engineering sciences and statistics. The full story is available here.
|Congratulations to Krista, who successfully defended her Ph.D. thesis today.|
Congratulations to Andrea, who was awarded a CIHR Banting and Best Canada Graduate Scholarship at the Master’s degree level for 2012-13!.
Congratulations to Haijiao, who won 3rd place in the Master’s Student Paper Competition (Tissue and Cellular Engineering) at the ASME 2012 Summer Bioengineering Conference for his poster titled “Characterization of the elasticity of valve interstitial cells on soft substrates by atomic force microscopy”!
Congratulations to Matthew, who was awarded a Heart & Stroke/Richard Lewar Centre of Excellence Postdoctoral Fellowship!
Congratulations to Wing-Yee, who successfully defended her Ph.D. thesis today.
Congratulations to Michelle, who was awarded the 2012 Centennial Thesis Award for the best undergraduate thesis in Mechanical Engineering!
Congratulations to Mark, who received an Honourable Mention for his poster at the CIHR National Research Poster Competition at the CIHR Canadian Student Health Research Forum (CSHRF), a conference for the top 5% of doctoral students in Canada.
Congratulations to Noam, Agnes, Justin, and Andrea, who were all awarded Ontario Graduate Scholarships for 2012-13!
Congratulations to Mark and Kelly, who were recognized for their research at the 18th annual Canadian Connective Tissue Conference in Toronto. Mark received 3rd place in the poster presentation competition, and Kelly received an honourable mention in the graduate student oral presentation competition.
Congratulations to Jenna, who was awarded a prestigious two year NSERCPGS-D Scholarship!
Congratulations to Team Heart Valve, who completed the 50-km Becel Heart & Stroke Ride for Heart on June 3. The team, comprised of 11 lab members and friends, raised $4,325 for the Heart & Stroke Foundation. Thanks to all of our generous sponsors!
Congratulations to Mark, who won 2nd place in the Young Investigator competition at the 2012 Heart Valve Biology and Tissue Engineering Meeting in Greece.
Congratulations to several undergraduate students in the lab who received scholarships to perform research in the lab this summer. Michelle, Xiaofan, and Moussa all received NSERC Undergraduate Student Research Awards (USRAs); David received a UROP Summer Researcher Award; and Kathak received an award from the Dentistry Summer Student program.
Congratulations to Mark, who received a travel award from CIHR to attend the Institute of Circulatory and Respiratory Health (ICRH) Young Investigators Forum in Montreal from June 4-6, 2012.
Congratulations to Mark, who was selected to attend the CIHR Canadian Student Health Research Forum (CSHRF) in Winnipeg, MB from June 12-14, 2012. The CSHRF provides a venue for health research trainees from across Canada to present their work, network and be recognized for the excellence of their contributions. More details are available here:http://www.umanitoba.ca/faculties/medicine/research_days/index.html. Mark was selected as one of the top 5% of doctoral students at the University of Toronto.
Congrats to Michelle, who was recognized by the University of Toronto for her outstanding extra-curricular contributions to improving the university’s community with a 2012 Gordon Cressy Student Leadership Award.
Congratulations to Kristine, Cindy, Zahra, Xiaofan, and Jan, whose paper “The elastic properties of valve interstitial cells undergoing pathological differentiation” was published in Journal of Biomechanics.
Srigunapalan S*, Eydelnant IA*, Simmons CA, Wheeler AR. A digital microfluidic platform for primary cell culture and analysis. Lab Chip, 2012;12:369-75. | PubMed
Zhao R, Simmons CA. An improved texture correlation algorithm to measure substrate-cytoskeletal network strain transfer under large compressive strain. J Biomech, 2012;45:76-82.| PubMed
Cheung WY, Simmons CA#, You L#. Osteocyte apoptosis regulates osteoclast precursor adhesion via osteocytic IL-6 secretion and endothelial ICAM-1 expression. Bone, 2012;50:104-110.| PubMed
Liu J*, Moraes C*, Lu Z, Simmons CA, Sun Y. Single cell deposition. Methods Cell Biol, 2012;112:403-420.| PubMed
Congratulations to Bogdan, who successfully defended his MASc thesis today!
Congratulations to Aleks, Haijiao, and Richard, who were awarded Barbara and Frank Milligan Fellowships from the Department of Mechanical & Industrial Engineering for 2011/12.
Congratulations to Suthan, whose NSERC PGS was converted to a 3 year Canada Graduate Scholarship (CGS-D)!
Congratulations to Ruogang, whose paper “An improved texture correlation algorithm to measure substrate-cytoskeletal network strain transfer under large compressive strain” was published in the Journal of Biomechanics.
Rajamannan NM, Evans FJ, Aikawa E, Grande-Allen KJ, Demer LL, Heistad DD, Simmons CA, Masters KS, Mathieu P, O’Brien KD, Schoen FJ, Towler DA, Yoganathan AP, Otto CM. Calcific aortic valve disease: not simply a degenerative process: A review and agenda for research from the National Heart and Lung and Blood Institute Aortic Stenosis Working Group Executive Summary: Calcific aortic valve disease – 2011 update. Circulation,2011;124:1783-91.| PubMed
The review and agenda for research from the NIH National Heart Lung and Blood Institute Aortic Stenosis Working Group, of which Craig was a member, was published in Circulation.
Moraes C, Sun Y#, Simmons CA#. (Micro) managing the mechanical microenvironment. Integr Biol, 2011;3:959-971.| PubMed
Congratulations to Wing-Yee, whose paper “Osteocyte apoptosis regulates osteoclast precursor adhesion via osteocytic IL-6 secretion and endothelial ICAM-1 expression.” was accepted for publication in Bone.
Young EWK, Wheeler AR, Simmons CA. Avoiding bubble injection by droplet merging. Chips & Tips (online supplement to Lab on a Chip), Oct. 23, 2006. | PubMed
Congratulations to Noam, who was awarded an NSERC Alexander Graham Bell Canada Graduate Scholarship (CGS-M) and a Mary H. Beatty Fellowship for 2011-2012!
Congratulations to Justin, who was awarded an NSERC Canada Graduate Scholarship (CGS-M) for 2011-12.
Congratulations to Agnes, who was awarded an NSERC Canada Graduate Scholarship (CGS-M) for 2011-12.
Congratulations to Aleks and Jenna who were awarded scholarships from the NSERC CREATE Program in Microfluidic Applications and Training in Cardiovascular Health (MATCH).
Congratulations to Jenna, who was awarded a Queen Elizabeth II – Graduate Scholarship in Science and Technology for 2011-12.
Our undergraduate researchers showed exceptionally well at Undergraduate Engineering Research Day (UnERD), with Meena, Michelle, Mike, Vanessa, and Xiaofan all doing outstanding presentations and earning high praise for their talks and posters. Xiaofan was awarded best oral presentation in his session, and Meena, Michelle, and Mike all were runners-up in their poster sessions. Congratulations!
Congratulations to Jan, who succesfully defended his Ph.D. thesis today!
Chris’ review article is accepted for publication in Integrative Biology. This article explores and reviews the role microfabricated systems can play in understanding how mechanical components of the microenvironment drive biological function.
Krista’s and Mark’s review article published in the International Journal of Inflammation. This open access article is part of a special issue on cardiovascular inflammation. In the article, animal models of calcific aortic valve disease are critically reviewed.
Sharifpoor S, Simmons CA, Labow RS, Paul Santerre J. Functional characterization of human coronary artery smooth muscle cells under cyclic mechanical strain in a degradable polyurethane scaffold. Biomaterials,2011;32:4816-4829.| PubMed
Congratulations to Krista, who won a Doctoral Completion Award from the School of Graduate Studies
Chen JH, Simmons CA. Cell–matrix interactions in the pathobiology of calcific aortic valve disease. Circ Res,2011;108:1510-1524.| PubMed
Congratulations to Kelly and Suthan, who won CMC Microsystems Best Poster Awards at the 2011 Ontario-on-a-Chip/MATCH Symposium.
Congratulations to Team Heart Valve, who completed the 50 km Ride for Heart today. The Team, comprised this year of 16 lab members, friends, and family members, raised $4,685 for the Heart and Stroke Foundation, by far the most we have raised to date.
Ruogang and Krista’s collaborative work with students in the Radisic Lab was published in and featured on the front cover of Biotechnology and Bioengineering. The cover can be viewed here.
Congratulations to Aleks, who won the Young Investigator Award at the 2011 MIE Research Symposium for his talk on “The mechanical properties of diseased aortic valve tissue”.
Congratulations to Suthan, who won *two* best poster awards at The 6th International Conference on Microtechnologies in Medicine and Biology (MMB 2011) in Lucerne, Switzerland! Suthan’s posters were on digital microfluidics for primary cell culture and a membrane microfluidic device to mimic the vascular microenvironment.
Yip CYY, Simmons CA. The aortic valve microenvironment and its role in calcific aortic valve disease.Cardiovascular Pathology,2011;20:177-182.| PubMed
Chen WLK, Simmons CA. Lessons from (patho)physiological tissue stiffness and their implications for drug screening, drug delivery and regenerative medicine. Advanced Drug Delivery Reviews, 2011;63:269-276.| PubMed
Congratulations to Mark, who was awarded a CIHR Frederick Banting and Charles Best Canada Graduate Scholarship (CGS)-Doctoral Award! Mark’s application was ranked 3rd of 941 applications in the competition.
Cheung WY, Liu C, Tonelli-Zasarsky RML, Simmons CA#, You L#. Osteocyte apoptosis is mechanically regulated and induces angiogenesis in vitro. J Orthop Res, 2011;29:523-530.| PubMed
Srigunapalan S, Lam C, Wheeler AR, Simmons CA. A microfluidic membrane device to mimic critical components of the vascular microenvironment. Biomicrofluidics, 2011;5:13409.| PubMed
Congratulations to Wing-Yee, who was awarded an NSERC Postgraduate Scholarship – Doctoral (PGS-D) for 2011-12!
Congratulations to Chris, who was awarded the 2010 John Leyerle-Canadian Institute for Advanced Research (CIFAR) Prize for Interdisciplinary Research. This prize recognizes a doctoral dissertation from the University of Toronto that makes unusually significant and original contributions to its academic field, and is presented to one excellent graduate student who performed outstanding interdisciplinary research. Chris was selected as the clear winner.
Congratulations to Jan, who was awarded a prestigious NSERCPostdoctoral Fellow!
Congratulations to Suthan, who was awarded an NSERC Postgraduate Scholarship – Doctoral (PGS-D) for 2011-12!
Congratulations to Chris, who received one of four 2010-11 Engineering Science Teaching Assistant Awards for outstanding contributions to teaching!
Zhao R*, Sider KL*, Simmons CA. Measurement of layer-specific mechanical properties in multilayered biomaterials by micropipette aspiration. Acta Biomaterialia, 2011;7:1220-1227.| PubMed
Congratulations to Chris! His paper,”Semi-confined compression of microfabricated polymerized biomaterial constructs”, was accepted for publication in Journal of Micromechanics and Microengineering.
Congratulations to Ruogang, who successfully defended his Ph.D. thesis today!
Sider KL*, Blaser MC*, Simmons CA. Animal models of calcific aortic valve disease. Int J Inflam, 2011; 364310.| PubMed
Moraes C, Zhao R, Likhitpanichkul M, Simmons CA#, Sun Y#. Semi-confined compression of microfabricated polymerized biomaterial constructs. J Micromech Microeng, 2011;21.| PubMed
Congratulations to Suthan! His paper, “A microfluidic membrane device to mimic critical components of the vascular microenvironment” was accepted for publication in Biomicrofluidics!
Congratulations to Jan! His paper, “Beta-catenin mediates mechanically-regulated, TGF-beta 1-induced myofibroblast differentiation of aortic valve interstitial cells” was accepted for publication in Arteriosclerosis, Thrombosis, and Vascular Biology!
Congratulations to Mark for completing his qualifying exam!
Ruogang and Krista’s paper “Measurement of layer-specific mechanical properties in multilayered biomaterials by micropipette aspiration” has been accepted by Acta Biomaterialia.
Sharifpoor S, Simmons CA, Labow RS, Santerre JP. A study of vascular smooth muscle cell function under cyclic mechanical loading in a degradable polyurethane scaffold with optimized porosity. Acta Biomaterialia, 2010;6:4218-4228. | PubMed
Lu Z*, Moraes C*, Ye G, Simmons CA, Sun Y. Single cell deposition and patterning with a robotic system. PLoS One,2010;5:e13542.| PubMed
Chris was awarded the 2010 Norman F. Moody Award. The Moody award was established in 1974 on the occasion of the retirement of the founder and first director of the Institute of Biomaterials and Biomedical Engineering at the University of Toronto. It is awarded annually to a graduate student inIBBME in recognition of his or her academic excellence.
Congratulations to Aleks who was awarded an NSERC CREATE Program in Microfluidic Applications and Training in Cardiovascular Health (MATCH) Scholarship for 2010-11.
Wing-Yee’s paper “Osteocyte Apoptosis is Mechanically Regulated and Induces Angiogenesis In Vitro” has been accepted by the Journal of Orthopedic Research.
Congratulations to Chien, who won Best Podium Presentation in the Biomedical Engineering session at the 2010 Undergraduate Engineering Research Day (UnERD) for his talk titled “Wnt3A inhibits TGF-beta1-induced apoptosis in aortic valvular endothelial cells”.
Congratulations to Wing-Yee, who won a Young Investigator Travel Grant to attend the 2010 American Society for Bone and Mineral Research meeting where she will give a podium presentation on “Osteocyte Apoptosis Promotes Angiogenesis and Osteoclast Precursor Adhesion In Vitro”
Congratulations to Kelly, who won a Travel Grant from the American Society for Bone and Mineral Research to attend the European Calcified Tissue Society PhD Training Course in Berlin, Germany.
Eilaghi A, Flanagan JG, Tertinegg I, Simmons CA, Brodland GW, Ethier CR. Biaxial mechanical testing of human sclera. J Biomech, 2010;43:1696-1701. | PubMed
Congratulations to Craig, who received tenure in the Department of Mechanical and Industrial Engineering, the Faculty of Dentistry, and the Institute of Biomaterials and Biomedical Engineering.
Congratulations to Suthan, who was awarded an Ontario Graduate Scholarship in Science and Technology for 2010-11.
Yuen A, Laschinger C, Talior I, Lee W, Chan M, Birek J, Young EWK, Sivagurunathan K, Won E, Simmons CA, McCulloch CA. Methylglyoxal-modified collagen promotes myofibroblast differentiation. Matrix Biology, 2010;29:537-48. | PubMed
Congratulations to Kelly, who received travel grants from the World Congress of Biomechanics and the CIHR Institute of Musculoskeletal Health and Arthritis to attend the World Congress of Biomechanics in Singapore where she will give an oral presentation.
Moraes C, Sun Y, Simmons CA. Chips & Tips: Connector-less manipulation of small liquid volumes in microchannels. www.rsc.org/Publishing/Journals/lc/microchannels.asp, Lab Chip, June 11, 2010.| PubMed
Congratulations to Wing-Yee, who was awarded an Ontario Graduate Scholarship for 2010-11.
Congratulations to Chris, who won the best oral presentation award at the Ontario-on-a-chip/MATCH 2010 symposium!
Congratulations to Kristine for getting into Med school at U of T!
Moraes C, Wyss K, Brisson E, Keith BA, Sun Y, Simmons CA. An undergraduate lab (on-a-chip): Probing single cell mechanics on a microfluidic platform. Cellular and Molecular Bioengineering, 2010;3:319-330. | PubMed
Fiddes LK, Raz N, Srigunapalan S, Tumarkan E, Parkharenko V, Simmons CA, Wheeler AR, Kumacheva E. A circular cross-section PDMS microfluidics system for replication of cardiovascular flow conditions. Biomaterials,2010;31:3459-3464. | PubMed
Congratulations to Rachel and Chien, who received CIHR Institute of Musculoskeletal Health and Arthritis Studentships, and to Cam, who received an NSERC Undergraduate Student Research Award. These awards support their summer research internships in the lab.
Congratulations to Ruogang, who won the best poster presentation at the MIE Research Symposium! Congratulations to Chris, who received Honourable Mention for his oral presentation.
Congratulations to Craig, who has been awarded the McCharles Prize for Early Career Research Distinction in the Faculty of Applied Science and Engineering! Read the story here: http://www.mie.utoronto.ca/enews/enews40.html
Congratulations to Mark and Kelly, who were awarded Ontario Graduate Scholarships!
Congratulations to Derek and Christy on the birth of Colin Randall on April 16, 2010.
Congratulations to Krista for being awarded the Doctoral Research Award from the Heart and Stroke Foundation of Canada for 2010-2012!
Eilaghi A, Flanagan JG, Simmons CA, Ethier CR. Effects of scleral stiffness properties on optic nerve head biomechanics. Ann Biomed Eng, 2010;38:1586-1592. | PubMed
Congratulations to Chris who received a NSERC Postdoctoral Fellowship!
Congratulations to Cindy who received a NSERC Industrial Postdoctoral Fellowship!
Congratulations to Kelly who received a NSERC PGS-D scholarship for 2010-2013!
Chen WLK, Likhitpanichkul M, Ho A, Simmons CA. Integration of statistical modeling and high-content microscopy to systematically investigate cell-substrate interactions. Biomaterials, 2010;31:2489-2497.| PubMed
Congratulations to Suthan who received a Travel Award to the CIHR Institute of Circulatory and Respiratory Health (ICRH) 2010 Young Investigators Forum to be held in Vancouver, BC from May 5-7th!
Congratulations to Mark for being awarded a Barbara and Frank Milligan Graduate Fellowship for 2009-2010!
Young EWK, Watson ML, Srigunapalan S, Wheeler AR, Simmons CA. Technique for real-time measurements of endothelial permeability in a microfluidic membrane chip using laser-induced fluorescence detection. Anal Chem,2010;82:808-816.| PubMed
Congratulations to Edmond, whose review article “Macro- and microscale fluid flow systems for endothelial cell biology” is featured on the front cover of this month’s Lab on a Chip. The full cover can be viewed here: http://pubs.rsc.org/en/content/articlelanding/2010/lc/b925937f/unauth
Congratulations to Krista and Jan, who have been awarded the Young Investigator Award at the 4th Biennial Heart Valve Biology and Tissue Engineering meeting.
Moraes C, Chen J-H, Sun Y, Simmons CA. Microfabricated arrays for high-throughput screening of cellular response to cyclic substrate deformation. LabChip, 2010;10:227-234. | PubMed
Chen JH, Liu C, You L, Simmons CA. Boning up on Wolff’s Law: Mechanical regulation of the cells that make and maintain bone. J Biomech, 2010;43:108-118.| PubMed
Moraes C, Wang GH, Sun Y, Simmons CA. A microfabricated platform for high-throughput unconfined compression of micropatterned biomaterial arrays. Biomaterials, 2010;31:577-584.| PubMed
Rask F*, Mihic A*, Reis L, Dallabrida SM, Ismail NS, Sider KL, Simmons CA, Rupnick MA, Weisel RD, Li R, Radisic M. Hydrogels modified with QHREDGS peptide support cardiomyocyte survival in vitro and after sub-cutaneous implantation. Soft Matter,2010;95:105-117.| PubMed
Congratulations to Craig and Deb who welcomed their first baby on December 19, 2009 at 1:16am (Year of the Ox)! At birth, she weighed 6 lbs, 13 oz and was 21” long.
Congratulations to Cindy, who successfully defended her Ph.D. thesis today!
Congratulations to Kelly! Her paper “Integration of statistical modeling and high-content microscopy to systematically investigate cell-substrate interactions” was accepted for publication in Biomaterials. Congratulations also to Morakot and Anthony who co-authored the paper.
Congratulations to Edmond! His paper “Technique for real-time measurements of endothelial permeability in a microfluidic membrane chip using laser-induced fluorescence detection” was accepted for publication in Analytical Chemistry. Congratulations also to Suthan, a co-author on the paper.
Brooks PJ, Nilforoushan D, Manolson MF, Simmons CA, Gong S-G. Molecular markers of early orthodontic tooth movement.Angle Orthod, 2009; 79:1108-1113.| PubMed
Congratulations to Chris! His paper “Microfabricated arrays for high-throughput screening of cellular response to cyclic substrate deformation” was accepted for publication in Lab on a Chip. Congratulations also to Jan, who is a co-author on the paper.
Edmond was awarded the 2009 Norman F. Moody Award. The Moody award was established in 1974 on the occasion of the retirement of the founder and first director of the Institute of Biomaterials and Biomedical Engineering at the University of Toronto. It is awarded annually to a graduate student inIBBME in recognition of his or her academic excellence.
Moraes C, Kagoma YK, Beca BM, Tonelli-Zasarsky RLM, Sun Y, Simmons CA. Integrating polyurethane culture substrates into multilayer poly(dimethylsiloxane) microdevices. Biomaterials, 2009;30:5241-5250.| PubMed
Congratulations to Chris! His paper “A microfabricated platform for high-throughput unconfined compression of micropatterned biomaterial arrays”, was published in Biomaterials!
Congratulations to Edmond! His paper “Macro- and microscale fluid flow systems for endothelial cell biology”, was published in Lab on a Chip!
Joyce was awarded 2nd place in the IBBME Summer Student Poster Competition for her poster titled “Macroscale and microscale fluid-induced mechanobiological responses in aortic endothelial cells”. Congratulations to Joyce, and to Jennifer, Jamie, and Lina were also cited by the judges for excellent presentations and posters.
Ruogang and Kristine’s paper, “Comparison of analytical and inverse finite element approaches to estimate cell viscoelastic properties by micropipette aspiration”, was accepted for publication in the Journal of Biomechanics.
Congratulations to Andrea, who successfully defended her M.Sc. thesis in the Orthodontics Graduate Specialty Program! Andrea’s thesis, co-supervised by Dr. Siew-Ging Gong and Craig, is titled “Development of a three-dimensional in vitro model system to study orthodontic tooth movement”. Andrea also passed her board exams earlier this year and will be opening her own orthodontics practice in Toronto in the fall. Congratulations, Andrea!
Congratulations to Edmond, whose paper describing a microfluidics lab to study blood flow in small vessels was accepted for publication in the Journal Chemical Engineering Education.
Team Heart Valve, made up of fourteen lab members and friends, completed the 50 km 2009 Ride for Heart, raising $2,620 in donations to support the Heart and Stroke Foundation of Ontario! Thanks to all of our generous sponsors!
Congratulations to Chris. His paper describing methods to integrate polyurethane substrates into microdevices was accepted for publication in the journal Biomaterials. Congratulations also to Yoan, Bogdan, and Rachel, three undergraduate students who helped with the research and are co-authors on the paper.
Congratulations to all the new summer research students who received scholarships for the summer. Bogdan was awarded a John D. Schultz Science Student Scholarship from the Heart and Stroke Foundation of Ontario. Jennifer received an NSERC USRA. Lina was awarded a University of Toronto Life Sciences Scholarship. And Joyce received a scholarship from the Dentistry Summer Student Program.
Simmons CA. Aortic valve mechanics: an emerging role for the endothelium. J Am Coll Cardiol, 2009;53:1456-1458. | PubMed
Congratulations to Ruogang and Jan, who were awarded Ontario Graduate Scholarships for 2009-10.
Craig’s invited commentary was published in the Journal of the American College of Cardiology. The paper comments on a recent paper from the Yacoub and Yoganathan groups on the role of the endothelium in regulating aortic valve mechanics.
Congratulations to Chris. His paper on a new technique to rapidly construct multilayered microdevices with stringent alignment requirements was accepted for publication in the Journal of Micromechanics and Microengineering.
Congratulations to Suthan, who was awarded an Ontario Graduate Scholarship for 2009-10.
Congratulations to Ruogang for being awarded the Doctoral Research Award from the Heart and Stroke Foundation of Canada for 2009-2011.
Congratulations to Jan for being awarded a prestigious NSERC Canada Graduate Scholarship (CGS-D) for 2009-2011.
Congratulations to Craig, who has been awarded the Early Career Teaching Award in the Faculty of Applied Science and Engineering! Read the story here: http://www.enews.engineering.utoronto.ca/june10_09/news11.html
Congratulations to Cindy, whose paper was accepted in Arteriosclerosis, Thrombosis and Vascular Biology! Her paper is the first to demonstrate regulation of calcification by valve interstitial cells by the stiffness of the extracellular matrix.
Chen JH, Yip CY, Sone ED, Simmons CA. Identification and characterization of aortic valve mesenchymal progenitor cells with robust osteogenic calcification potential. Am J Pathology, 2009;174:1109-1119. | Pubmed
Fiddes L, Chan HK, Wyss K, Simmons CA, Kumacheva E, Wheeler AR. Augmenting microgel flow via receptor-ligand binding in the constrained geometries of microchannels. Lab Chip, 2009;9:286-290.| PubMed
Young EWK, Simmons CA. “Student lab”-on-a-chip: Integrating low-cost microfluidics into undergraduate teaching labs to study multiphase flow phenomena in small vessels. Chem Eng Educ, 2009;43:232-240.| PubMed
Moraes C, Sun Y, Simmons CA. Solving the shrinkage-induced PDMS alignment registration issue in multilayer soft lithography. J Micromech Microeng, 2009;19:065015.| PubMed
Congratulations to Edmond, who successfully defended his Ph.D. thesis today! Edmond will be moving to the University of Wisconsin in the New Year to start an NSERC Postdoctoral Fellowship in the lab of Dave Bebbe.
Congratulations to Jan for getting his paper accepted in the American Journal of Pathology! Jan’s paper is the first to identify and characterize mesenchymal progenitor cells with robust osteogenic potential in aortic heart valves.
Congratulations to Suthan who was awarded a Barbara and Frank Milligan Graduate Fellowship from the Department of Mechanical and Industrial Engineering for 2008-09.
Wing-Yee and Edmond’s paper on valve endothelial cell isolation techniques is published in the Journal of Heart Valve Disease.
Cheung WY*, Young EWK*, Simmons CA. Techniques for isolating and purifying porcine aortic valve endothelial cells. J Heart Valve Dis, 2008;17:674-681.| PubMed
Congratulations to Cindy who won the Canadian Society of Atherosclerosis, Thrombosis, and Vascular Biology Young Investigator Award for the best oral presentation at the 2008 Canadian Cardiovascular Congress!
Chris gave a poster presentation at the 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, TAS 2008 Conference in San Diego, CA.
Edmond, Kristine, and Chris gave oral presentations at the 2008 Annual Biomedical Engineering Society (BMES) Meeting in St. Louis, MO. Also attending the meeting were Krista, Kelly, Cindy, and Craig.
Congratulations to Kelly who won a University of Toronto Bone and Mineral Group Scholarship for 2008-09!
Congratulations to Edmond, Kristine, and Chris who were awarded 2008 Biomedical Engineering Society (BMES) Student Travel Awards to present at the Annual BMES Meeting in St. Louis, MO. Only 40 of these awards were distributed this year.
Congratulations to Jan, Chris, and Wing-Yee who were awarded Ontario Graduate Scholarships in Science and Technology (OGGSTs) for 2008-09.
Congratulations to Cindy who was awarded an Ontario Graduate Scholarship for 2008-09!
Spiteri C, Young EWK, Simmons CA, Pilliar RM, Kandel RA. Substrate architecture and fluid-induced shear stress during chondrocyte seeding: Role of α5β1 integrin. Biomaterials, 2008; 29:2477-2489.| PubMed
Congratulations to Ali, who was awarded a CIHR Institute of Musculoskeletal Health and Arthritis Studentship!
Congratulations to Ali, Billy, Bogdan, Catherine, and Ian, who receivedNSERC Undergraduate Student Research Awards! Congratulations to Suthan, who received a John D. Schultz Science Student Scholarship from the Heart and Stroke Foundation of Ontario! And congratulations to Rachel, who received an Engineering Science Research Opportunity Program Fellowship!
Pho M, Lee W, Watt DR, Laschinger C, Simmons CA, McCulloch CA. Cofilin is a marker of myofibroblast differentiation in cells from porcine aortic cardiac valves. Am J Physiol Heart Circ, 2008;294:H1767-1778.| PubMed
Congratulations to Edmond who was awarded a two-year NSERCPostdoctoral Fellowship!
Big congratulations to Krista who was awarded a prestigious NSERCAlexander Graham Bell Canada Graduate Scholarship for 2008-2010!
Congratulations to Jan, who received a Young Investigator Award from the European Calcified Tissue Society to present a poster at the 35th European Symposium on Calcified Tissues in Barcelona in May! Jan’s abstract was ranked in the top 20 of all those submitted to the competition and will be considered for a Poster Prize.
Zahra is profiled in this month’s Engineering Newsletter!
Following up on November’s news of George receiving a Golden Key Undergraduate Research Grant, George is now featured on the Golden Key website as one of only three recipients of the grant!
Congratulations to Chris who received a Student Travel Award to give an oral presentation at the 8th World Biomaterials Conference in Amsterdam in June. Chris is one of only 35 recipients of this award selected from over 450 applications!
Congratulations to Jan who recieved the ASIP’s 2008 Trainee Travel Award and Cindy who was named the A.D. Sobel – ASIP Education Fund Scholar. These awards will support their travel to present at the Experimental Biology 2008 Meeting in San Diego, CA in April.
Butcher JT, Simmons CA, Warnock JN. Mechanobiology of the aortic heart valve. J Heart Valve Dis, 2008;17:62-73.| PubMed
Li W, Young EWK, Seo M, Nie Z, Garstecki P, Simmons CA, Kumacheva, E. Simultaneous microfluidic generation of droplets with different dimensions. Soft Matter, 2008;4:258-262.| PubMed
Tong J, Simmons CA, Sun Y. Precision patterning of PDMS membranes and applications. Journal Micromech Microeng,2008;18:037004 (5 pp).| PubMed
Happy New Year! Congratulations to Chris, Cindy and Edmond who received student travel awards to present at the SPRBM Annual Meeting in Miami, FL on January 10 2008!
Congratulations to Krista, Ruogang, Wing-Yee, Jan, and Chris for being awarded Barbara and Frank Milligan Graduate Fellowships for 2007-08!
Young EWK, Wheeler AR, Simmons CA. Matrix-dependent adhesion of vascular and valvular endothelial cells in microfluidic channels. Lab Chip, 2007;7:1759-1766.| PubMed
Congratulations to George, who was awarded a Golden Key Fall Undergraduate Research Grant from the Golden Key International Honour Society to support his thesis research! Bravo on an impressive accomplishment, George! Watch this space for the latest news, including a pending Golden Key press release featuring George’s headshot…
Congratulations to Cindy for her recent publication in the Journal of Bacteriology!
Congratulations to Edmond for his recent publication in Soft Matter!
A big congratulations to Derek (a.k.a. Master D) for passing his Master’s thesis defense!
The 2007 BMES conference took place in Los Angeles from September 26 – 29, and Craig and Edmond from the lab were there to participate. Craig (below) gave a sterling lecture on high-throughput mechanobiology, and presented current developments in that area that are being pursued within his own lab. Edmond presented his poster on matrix-dependent adhesion of vascular and valvular endothelial cells in microchannels. Also representing the University of Toronto was Irena Barbulovic-Nad (below) from the Wheeler Microfluidics Laboratory, who presented a poster on her novel work with droplet microfluidics and cell assays.
Craig wraps up his talk on high-throughput mechanobiology to a round of applause.
Irena Barbulovic-Nad from the Wheeler Microfluidics Laboratory discusses her work on droplet microfluidics and cell assays to a crowd of very enthusiastic and interested BMES attendees.
The Simmons Lab had a party at Craig and Deb’s to welcome the new students, and say goodbye to some former members. Good luck to Ron, Steph, and Emily on their future endeavors! And a warm official welcome to Krista and Kelly! Lab members only can click here for photos of the event.
We are pleased to welcome Zahra, our new research associate/technician, to the lab!
The Simmons Lab had their annual BBQ on Centre Island, and it was a blast!
Congratulations to Cindy, Jan, and Kristine for being appointed president, vice president, and treasurer respectively for the BMES Student Chapter (#100) at UofT! Edmond was also appointed secretary of the Student Chapter. For more information about the chapter and how to get involved, please email Edmond at email@example.com.
One featured poster from UTCML was presented by Ruogang Zhao, Emily Won, and Kristine Wyss on studying valve interstitial cell biology using micropipette aspiration.
Cindy Yip discusses matrix stiffness effects on valve interstitial cells to several of Dr. Gottlieb’s students, who also have experience working with VICs. The Joint Cardiovascular Research Day seems to have succeeded in bringing together researchers with similar interests.
Baosen Zhang, a former summer student in UTCML, presents his work on 3D hemodynamic shear stress predictions using CFD at the CANCAM 2007 Conference held at Ryerson University.
Congratulations to our newest lab members Ian Periera, Suthan Srigunapalan, George Ye, and Xiao Zhong, who were all awarded summer research scholarships
A really loud congratulations to Wing-Yee Cheung who was awarded a John D. Schultz Science Student Scholarship from the Heart and Stoke Foundation of Ontario for 2007!
Congratulations to Prof. Craig Simmons who has been appointed the Division of Engineering Science Biomedical Option Chair, effective July 1, 2007!
Congratulations to Kristine Wyss who was awarded an NSERC PGS M award for 2007-08!
Congratulations to Stephanie Ting and Emily Won who were both awarded an NSERC USRA for 2007!
Abstracts from Derek Watt and Cindy Yip accepted for oral presentation at the Society for Heart Valve Disease 4th Biennial Meeting in New York.
Congratulations to Chris Moraes who passed his Ph.D. qualification exam!
Chong SA, Lee W, Arora PD, Laschinger C, Young EWK, Simmons CA, Manolson M, Sodek J, McCulloch CA. Methylglyoxal inhibits the binding step of collagen phagocytosis. J Biol Chem, 2007; 282:8510-8520.| PubMed
Chris Moraes invited to speak on BioMEMS at the Undergraduate Nanotechnology Conference 2007 in Toronto on March 10, 2007.
Edmond Young and Cindy Yip receive travel awards to present their research at the Vascular Matrix Biology and Bioengineering Workshop sponsored by the North American Vascular Biology Organization.
Stephanie Ting awarded a prestigious graduate scholarship to study at the University of Tokyo.
Check out the recently published work in J Biol Chem by Chong et al (2007) from the CIHR Matrix Dynamics Group, with collaborative efforts from two members of UTCML.
Chris Moraes writes about the marriage between cell mechanics and MEMS in his latest publication in the Fall 2006 CSME Bulletin.
Congratulations to Jan for his appointment as the new UTCML social coordinator! “Jan has been a very vocal member of the lab when it comes to social activities, so I think this appointment is perfect for him”, said Cindy, the former social coordinator. “I’m pleased to be passing a fun job onto such capable hands.” And with that, the new social coordinator was crowned. UTCML looks forward to the social calendar of 2007!
Congratulations to Cindy on her success in her qualifying exam before the Christmas holidays!
UTCML wishes everyone a Happy and productive New Year!
Craig Simmons receives Early Researcher Award from the Ontario Ministry of Research and Innovation.
Moraes C, Simmons CA, Sun Y. Cell mechanics meets MEMS. CSME Bulletin, Fall 2006.| PubMed
The webpage has undergone some major work in the last days performed by Moritz, mainly to eliminate literally more than a thousand errors in the code, to make the code easier to maintain and more structured, but also for some small design changes. With the exception of the photo albums in the intranet pages (which will have to be tackled in the next days), all pages should now be truly valid XHTML 1.0 Strict and CSS – a prerequisite for having the pages displayed as similarly as possible in different browsers! Each page contains a link in the footer that can be used to validate the current page; if you do find errors, please report them to Edmond.
The Simmons Lab had a farewell lunch to thank the summer students for all their hard work in the past few months. Everyone indulged themselves with General Tao’s Chicken. By the end of the meal, we had Derek saying, “General Tao is my new best friend.
What a great event this turned out to be! Thanks to Craig for authorizing this day off, and to Cindy for organizing and carefully deciding on the delegation of tasks. There was frisbee, kite-flying, beach volleyball, soccer, and of course the food. All in all, a major success!!!
Congratulations to Jan Chen, Liwen Gu, Alice Ho, Kevin Lee, and Kristine Wyss on their graduation!
Kristine is beaming as a member of newest grad class from Engineering Science. Congrats, Kristine!
This year’s International Society for Heart Research (ISHR) Conference will be held right here in Toronto, Canada. UTLCM will have some representation at this conference as Alice Ho and Edmond Young will both be presenting posters.
|The new and improved UTLCM website was launched.|
We officially moved into our new facilities in the Rosebrugh Building! Everyone is anxious to get organized and to settle into the new digs. Check back for new updates and pictures of our move-in.
Several members of our lab attended the Centre for Clinical Technologies and Medical Devices (CCTMD) 2006 Mini Symposium (synopsis) that brought together renowned researchers as well as engineers and physicians in hopes of promoting collaborative opportunities for furthering development of clinical technologies.
The Simmons BioLab in Rosebrugh just received a new shipment of equipment. Please check back later for photos.
Congratulations are in order to Cindy Yip, who has just received her Master of Applied Science degree here at the University of Toronto (IBBME)!
UTLCM Christmas Dinner at the Old Spaghetti Factory a success! (Event organized by Cindy Yip, social coordinator).
The University of Toronto Laboratory of Cellular Mechanobiology (UTLCM) has planned a Christmas dinner for members and friends at the Old Spaghetti Factory on Friday, December 16th at 8:00pm. The members of the lab would like to thank Prof. Simmons for the invitation. (Event organized by Cindy Yip, social coordinator.)
The new office space in MC64 just got a boost! New desks and filing cabinets were moved into the space, and it is getting closer to being ready for full occupancy.
Cindy Yip was officially appointed social coordinator for the Simmons Lab of Cellular Mechanobiology at the University of Toronto.
Dr. Lorna J. Gibson, Department of Materials Science and Engineering, Massachusetts Institute of Technology, will be giving a special seminar on November 14, 2005, in Rosebrugh 208, from 12:00 noon – 2:00 pm.
The Simmons Laboratory of Cellular Mechanobiology will be moving into its new facilities in the Rosebrugh Building at the University of Toronto, St. George campus, starting in December 2005. Renovations are currently underway.
Huang YC, Simmons CA, Kaigler D, Rice KG, Mooney DJ. Bone regeneration in a rat cranial defect with delivery of PEI-condensed plasmid DNA encoding for bone morphogenetic protein-4 (BMP-4). Gene Ther, 2005;12:418-426.| PubMed
Murphy WL, Hsiong S, Richardson TP, Simmons CA, Mooney DJ. Effects of a bone-like mineral film on phenotype of adult human mesenchymal stem cells in vitro. Biomaterials, 2005; 26:303-310.| PubMed
Simmons CA, Nikolovski J, Thornton AJ, Matlis S, Mooney DJ. Mechanical stimulation and mitogen-activated protein kinase signaling independently regulate osteogenic differentiation and mineralization by calcifying vascular cells. J Biomech,2004;37:1531-1541.| PubMed
Simmons CA, Zilberberg J, Davies PF. A rapid, reliable method to isolate high quality endothelial RNA from small spatially-defined locations. Ann Biomed Eng, 2004;32:1453-1459.| PubMed
Simmons CA, Alsberg E, Hsiong S, Kim WJ, Mooney DJ. Dual growth factor delivery and controlled scaffold degradation enhance in vivo bone formation by transplanted bone marrow stromal cells. Bone, 2004;35:562-569.| PubMed
Davies PF, Passerini AG, Simmons CA. Aortic valve: turning over a new leaf(let) in endothelial phenotypic heterogeneity.Arterioscler Thromb Vasc Biol, 2004;24:1331-1333.| PubMed
Murphy WL*, Simmons CA*, Kaigler D, Mooney DJ. Bone regeneration via a mineral substrate and induced angiogenesis. J Dent Res, 2004;83:204-210.| PubMed
Simmons CA, Matlis S, Thornton AJ, Chen S, Wang CY, Mooney DJ. Cyclic strain enhances matrix mineralization by adult human mesenchymal stem cells via the extracellular signal-regulated kinase (ERK1/2) signaling pathway. J Biomech,2003;36:1087-1096.| PubMed
Simmons CA, Meguid SA, Pilliar RM. Mechanical regulation of localized and appositional bone formation around bone-interfacing implants. J Biomed Mater Res, 2001;55:63-71.| PubMed
Simmons CA, Meguid SA, Pilliar RM. Differences in osseointegration rate due to implant surface geometry can be explained by local tissue strains. J Orthop Res, 2001;19:187-194.| PubMed
Simmons CA, Valiquette N, Pilliar RM. Osseointegration of sintered porous-surfaced and plasma spray-coated implants: An animal model study of early postimplantation healing response and mechanical stability. J Biomed Mater Res, 1999;47:127-138.| PubMed
Simmons CA, Hipp JA. Method-based differences in the automated analysis of the three-dimensional morphology of trabecular bone. J Bone Miner Res, 1997;12:942-947.| PubMed
Hipp JA, Jansujwicz A, Simmons CA, Snyder BD. Trabecular bone morphology from micro-magnetic resonance imaging. J Bone Miner Res, 1996;11:286-297.| PubMed
Elke RP, Cheal EJ, Simmons C, Poss R. Three-dimensional anatomy of the cancellous structures within the proximal femur from computed tomography data. J Orthop Res, 1995;13:513-523.| PubMed