Bahram Mirani

Ph.D. Candidate
Institute of Biomaterials and Biomedical Engineering,
Department of Mechanical & Industrial Engineering.
Joined in 2018.

Research interests

  • Heart valve tissue engineering
  • Semilunar valve
  • 3D bioprinting

Contact Information
Office tel: 416-978-6432


Research Summary

Mechanical or bioprosthetic heart valve replacements, as the only treatment options for valvular heart disease, do not result in ideal outcomes due to the risk of blood coagulation or regradation, and particularly, are not suitable for young patients as they do not grow, remodel, and repair. Alternatively, tissue engineering of heart valve holds the promise of providing heart valves with regenerative capability. My research, primarily, focuses on the development of a tissue-engineered heart valve with mechanical, structural, and material properties similar to those of native heart valve tissue.

Recent News Publications
  • Parvin Nejad Shouka, Lecce Monica, Mirani Bahram, Siquiera Nataly M., Mirzaei Zahra, Santerre J Paul., Davies John E., Simmons Craig A. Serum- and xeno-free culture of human umbilical cord perivascular cells for pediatric heart valve tissue engineering. Stem Cell Research & Therapy. 2023 | BioMed Central

  • Sebastian Joseph A., Strohm Eric M., Chérin Emmanuel, Mirani Bahram, Démoré Christine, Kolios Michael C., Simmons Craig A. High-frequency quantitative ultrasound for the assessment of the acoustic properties of engineered tissues in vitro. Acta Biomaterialia. 2022 | Elsevier

  • Mirani Bahram, Parvin Nejad Shouka, Simmons Craig A. Recent progress toward clinical translation of tissue engineered heart valves. Canadian Journal of Cardiology. 2021 | Elsevier