|Technician III/Lab Manager
Institute of Biomaterials & Biomedical Engineering
Department of Mechanical & Industrial Engineering
Joined in 2007.
Training and assisting the students with their projects are parts of my job. My major project is to determine the signaling pathways involved in calcific aortic valve sclerosis. I am particularly interested in the mechanisms by which valve interstitial cells differentiate to calcifying phenotypes in response to mechanical stress.
- Krista, Andrea, and Zahra’s paper is accepted for publication in Cardiovascular Pathology!
- Kristine, Cindy, Zahra, Xiaofan, and Jan’s paper is published in Journal of Biomechanics!
- Zahra is profiled in this month’s Engineering Newsletter!
- We are pleased to welcome Zahra, our new research associate/technician, to the lab!
Zhong, Aileen, Mirzaei, Zahra, Simmons, Craig A. The Roles of Matrix Stiffness and ß-Catenin Signaling in Endothelial-to- Mesenchymal Transition of Aortic Valve Endothelial Cells. Cardiovascular Engineering and Technology. 2018;9:158-167|Springer
Blaser MC, Wei K, Adams RLE, Zhou YQ, Caruso LL, Mirzaei Z, Lam AY, Tam RKK, Zhang H, Heximer SP, Henkelman RM, Simmons CA. Deficiency of Natriuretic Peptide Receptor 2 Promotes Bicuspid Aortic Valves, Aortic Valve Disease, Left Ventricular Dysfunction, and Ascending Aortic Dilatations in Mice. Circulation Research. 2018; 2(122): 405-416 | PubMed
Loai S, Haedicke I, Mirzaei Z, Simmons CA, Zhang XA, Cheng HL. Positive-contrast cellular MRI of embryonic stem cells for tissue regeneration using a highly efficient T1 MRI contrast agent. J Magn Reson Imaging, 2016; 44:1456-1463| PubMed
Plaza GR, Uyeda TQP, Mirzaei Z, Simmons CA. Study of the influence of actin-binding proteins using linear analyses of cell deformability. Soft Matter, 2015;11:5435-46. | PubMed
Sider KL, Zhu C, Kwong AV, Mirzaei Z, De Lange CFM, Simmons CA. Evaluation of a porcine model of early aortic valve sclerosis. Cardiovasc Pathol, 2014;23:289-97.| PubMed
Heckler AF, Mirzaei Z, Pereira I, Simmons CA, Gong S-G. Development of a three-dimensional in vitro model system to study orthodontic tooth movement. Arch Oral Biol, 2013;58:1498-1510.| PubMed
Wyss K, Yip CYY, Mirzaei Z, Jin X, Chen JH, Simmons CA. The elastic properties of valve interstitial cells undergoing pathological differentiation. J Biomech, 2012;45:882-887. Supplemental material.| PubMed
Yip CY, Blaser MC, Mirzaei Z, Zhong X, Simmons CA. Inhibition of pathological differentiation of valve interstitial cells by C-type natriuretic peptide. Arterioscler Thromb Vasc Biol, 2011;31:1881-1889. Supplemental material| PubMed