Zahra Mirzaei

Laboratory Coordinator
Institute of Biomaterials & Biomedical Engineering
Department of Mechanical & Industrial Engineering
Joined in 2007.

Contact Information
Office Tel: 416-978-7365

Research Summary
Training and assisting the students with their projects are parts of my job. My major project is to determine the signaling pathways involved in calcific aortic valve sclerosis. I am particularly interested in the mechanisms by which valve interstitial cells differentiate to calcifying phenotypes in response to mechanical stress.

  • Parvin Nejad Shouka, Lecce Monica, Mirani Bahram, Siquiera Nataly M., Mirzaei Zahra, Santerre J Paul., Davies John E., Simmons Craig A. Serum- and xeno-free culture of human umbilical cord perivascular cells for pediatric heart valve tissue engineering. Stem Cell Research & Therapy. 2023 | BioMed Central

  • Zhong, Aileen, Mirzaei, Zahra, Simmons, Craig A. The Roles of Matrix Stiffness and ß-Catenin Signaling in Endothelial-to- Mesenchymal Transition of Aortic Valve Endothelial Cells. Cardiovascular Engineering and Technology. 2018;9:158-167|Springer

  • Blaser MC, Wei K, Adams RLE, Zhou YQ, Caruso LL, Mirzaei Z, Lam AY, Tam RKK, Zhang H, Heximer SP, Henkelman RM, Simmons CA. Deficiency of Natriuretic Peptide Receptor 2 Promotes Bicuspid Aortic Valves, Aortic Valve Disease, Left Ventricular Dysfunction, and Ascending Aortic Dilatations in Mice. Circulation Research. 2018; 2(122): 405-416 | PubMed

  • Loai S, Haedicke I, Mirzaei Z, Simmons CA, Zhang XA, Cheng HL. Positive-contrast cellular MRI of embryonic stem cells for tissue regeneration using a highly efficient T1 MRI contrast agent. J Magn Reson Imaging, 2016; 44:1456-1463| PubMed

  • Plaza GR, Uyeda TQP, Mirzaei Z, Simmons CA. Study of the influence of actin-binding proteins using linear analyses of cell deformability. Soft Matter, 2015;11:5435-46. | PubMed

  • Sider KL, Zhu C, Kwong AV, Mirzaei Z, De Lange CFM, Simmons CA. Evaluation of a porcine model of early aortic valve sclerosis. Cardiovasc Pathol, 2014;23:289-97.| PubMed

  • Heckler AF, Mirzaei Z, Pereira I, Simmons CA, Gong S-G. Development of a three-dimensional in vitro model system to study orthodontic tooth movement. Arch Oral Biol, 2013;58:1498-1510.| PubMed

  • Wyss K, Yip CYY, Mirzaei Z, Jin X, Chen JH, Simmons CA. The elastic properties of valve interstitial cells undergoing pathological differentiation. J Biomech, 2012;45:882-887. Supplemental material.| PubMed

  • Yip CY, Blaser MC, Mirzaei Z, Zhong X, Simmons CA. Inhibition of pathological differentiation of valve interstitial cells by C-type natriuretic peptide. Arterioscler Thromb Vasc Biol, 2011;31:1881-1889. Supplemental materialPubMed