29 Jun

Dou Wenkun, Malhi Manpreet, Cui Teng, Wang Minyao, Wang Tiancong, Shan Guanqiao, Law Junhui, Gong Zheyuan, Plakhotnik Julia, Filleter Tobin, Li Renke, Simmons Craig A., Maynes Jason T., Sun Yu. A carbon-based biosensing platform for simultaneously measuring the contraction and electrophysiology of iPSC-cardiomyocyte monolayers. ACS Nano. 2022 | American Chemical Society

29 Jun

Wong Edwin KY., Parvin Nejad Shouka, D’Costa Katya A., Machado Siqueira Nataly, Lecce Monica, Santerre Paul, Simmons Craig A. Design of a mechanobioreactor to apply anisotropic, biaxial strain to large thin biomaterials for tissue engineered heart valve applications. Annals of Biomedical Engineering. 2022 | Springer

30 May

Nouri Shahrzad, Holcroft James, Caruso Laura-lee, Vuong Thu V., Simmons Craig A., Master Emma R., Ganss Berhnhard. An SCPPPQ1/LAM332 protein complex enhances the adhesion and migration of oral epithelial cells: Implications for dentogingival regeneration. 2022 | Elsevier.

28 Feb

Dou Wenkun, Malhi Manpreet, Zhao Qili, Wang Li, Huang Zongjie, Law Junhui, Liu Na, Simmons Craig A., Maynes Jason T., Sun Yu. Microengineered platforms for characterizing the contractile function of in vitro cardiac models. 2022 | Springer Nature

06 Jan

Persson Henrik, Park Siwan, Mohan Michael, Cheung Ka Kit, Simmons Craig A., Young Edmond WK. Rapid assembly of PMMA microfluidic devices with PETE membranes for studying the endothelium. Sensors and Actuators B: Chemical. 2021 | Elsevier

06 Jan

McClarty Davis, Ouzounian Maral, Tang Mingyi, Eliathamby Daniella, Romero David, Nguyen Elsie, Simmons Craig A., Amon Cristina, Chung Jennifer C-Y. Ascending aortic aneurysm haemodynamics are associated with aortic wall biomechanical properties. European Journal of Cardio-Thoracic Surgery. 2021 | Oxford Academic

22 Oct

Anthonyshyn Jeremy A., Mazzoli Vienna, McFadden Meghan J., Gramolini Anthony O., Hofer Stefan O. P., Simmons Craig A., Santerre, Paul. Mitigating the non-specific uptake of immunomagnetic microparticles enables the extraction of endothelium from human fat. Communications Biology. 2021 | Nature Publishing Group

09 Oct

Tang Mingyi, Eliathamby Daniella, Ouzounian Maral, Simmons Craig A, Chung Jennifer C.-Y. Dependency of energy loss on strain rate, strain magnitude and preload: Towards development of a novel biomarker for aortic aneurysm dissection risk. Journal of the Mechanical Behavior of Biomedical Materials. 2021 | Elsevier

17 May

Liu Haijao, Usprech Jenna F., Parameshwar Prabu K., Sun Yu, Simmons Craig A. Combinatorial screen of dynamic mechanical stimuli for predictive control of MSC mechano-responsiveness. Science Advances. 2021 | AAAS

10 Mar

Dou Wenkun, Wang Li, Malhi Manpreet, Liu Haijao, Zhao Qili, Plakhotnik Julia, Xu Zhensong, Huang Zongjie, Simmons Craig A., Maynes Jason T., Sun Yu. A microdevice platform for characterizing the effect of mechanical strain magnitudes on the maturation of iPSC-Cardiomyocytes. Biosensors and Bioelectronics. 2021 | Elsevier

29 Dec

Maleki Hoda, Doyle Matthew G., Chehade Moussa, Liu Qian, Simmons Craig A. The focal mechanical properties of normal and diseased porcine aortic valve tissue measured by a novel microindentation device. Journal of the Mechanical Behavior of Biomedical Materials. 2020 | Elsevier.

29 Dec

Dou Wenkun, Wang Li, Malhi Manpreet, Liu Haijao, Zhao Qili, Plakhotnik Julia, Xu Zhensong, Huang Zongjie, Simmons Craig A., Maynes Jason T., Sun Yu. A microdevice platform for characterizing the effect of mechanical strain magnitudes on the maturation of iPSC-Cardiomyocytes. Biosensors and Bioelectronics. 2020 | Elsevier

29 Dec

Fitzsimmons Ross E.B., Ireland Ronald G., Zhong Aileen., Soos Agnes, Simmons Craig A., Assessment of fibrin-collagen co-gels for generating microvessels ex vivo using endothelial cell-lined microfluidics and multipotent stromal cell (MSC)-induced capillary morphogenesis. Biomedical Materials. 2020 | IOP Science.

25 Aug

Chung Jennifer C-Y., Wong Edwin, Tang Mingyi, Eliathamby Daniella, Forbes Thomas L., Butany Jagdish, Simmons Craig A., Ouzounian Maral, Biomechanics of Aortic Dissection: A Comparison of Aortas Associated With Bicuspid and Tricuspid Aortic Valves. Journal of the American Heart Association. 2020 | Wiley 

25 Aug

Callaghan Neal I., Lee Shin-Haw, Hadipour-Lakmehsari Sina, Lee Xavier A., Siraj M. Ahsan, Driouchi Amine, Yip Christopher M., Husain Mansoor,Simmons Craig A., Gramolini Anthony O., Functional culture and in vitro genetic and small-molecule manipulation of adult mouse cardiomyocytes. Communications Biology. 2020 | Nature Publishing Group 

25 Aug

Ireland Ronald G., Kibschull Mark, Audet Julie, Ezzo Maya, Hinz Boris, Lye Stephen J., Simmons Craig A., Combinatorial extracellular matrix microarray identifies novel bioengineered substrates for xeno-free culture of human pluripotent stem cells. Biomaterials. 2020 | Elsevier

25 Aug

Gellner Bryan, Xin Liming, Ribeiro Roberto V.P., Bissoondath Ved, Lu Pengzhoi, Adamson Mitchell B., Yu Frank, Paradiso Emanuela, Zu Jean, Simmons Craig A., Badiwala Mitesh V., The implementation of an adjustable afterload module during ex situ heart perfusion. Cardiovascular Engineering and Technology. 2020 | Springer

25 Aug

Gellner Bryan, Xin Liming, Ribeiro Roberto V.P., Bissoondath Ved, Adamson Mitchell B., Yu Frank, Lu Pengzhou, Paradiso Emanuela, Hondjeu Arnaud R.M., Simmons Craig A., Badiwala Mitesh V., The implementation of physiological afterload during ex situ heart perfusion augments prediction of posttransplant function. American Journal of Physiology – Heart and Circulatory Physiology. 2020 | American Physiological Society

25 Aug

Wong Jeremy F., Mohan Michael D., Young Edmond W.K., Simmons Craig A., Integrated electrochemical measurement of endothelial permeability in a 3D hydrogel-based microfluidic vascular model. Biosensors and Bioelectronics. 2020 | Elsevier

23 Aug

Hadipour-Lakmehsari Sina, Driouchi Amine, Lee Shin-Haw, Kuzmanov Uros, Callaghan Neal I., Heximer Scott P., Simmons Craig A., Yip Christopher M., Gramolini Anthony O., Nanoscale reorganization of sarcoplasmic reticulum in pressure-overload cardiac hypertrophy visualized by dSTORM. Scientific Reports. 2019 | Nature Publishing Group 

19 Feb

Callaghan Neal, Hadipour-Lakmehsari Sina, Lee Shin-Haw, Gramolini Anthony O., Simmons Craig A., Modeling cardiac complexity: Advancements in myocardial models and analytical techniques for physiological investigation and therapeutic development in vitro. APL Bioengineering. 2019 | AIP

22 Aug

Lam Alan Y, Simmons Craig A., Cell and Extracellular Matrix Interactions in a Dynamic Biomechanical Environment: The Aortic Valve as an Illustrative Example. In: Labrosse MR, eds. Cardiovascular Mechanics. Boca Raton, FL: CRC Press; 2018. | Book Chapter

29 Jun

Fitzsimmons Ross EB, Aquilino Mark S., Quigley Jasmine, Chebotarev Oleg, Tarlan Farhang, Simmons Craig A. Generating vascular channels within hydrogel constructs using an economical open-source 3D bioprinter and thermoreversible gels. Bioprinting: 2018; 9:7-18 | ScienceDirect

29 Jun

Zhong, Aileen, Mirzaei, Zahra, Simmons, Craig A. The Roles of Matrix Stiffness and ß-Catenin Signaling in Endothelial-to- Mesenchymal Transition of Aortic Valve Endothelial Cells. Cardiovascular Engineering and Technology. 2018;9:158-167|Springer

30 Oct

Zhang Xiaoqing, Battiston Kyle, Simmons Craig A, Santerre J Paul. Differential regulation of extracellular matrix components by using different vitamin C derivatives in mono-and co-culture systems. ACS Biomaterials Science & Engineering. 2017 | ACS

30 Oct

Leung General, Kirpalani Anish, Szeto Stephen G, Deeb Maya, Warren Foltz,  Simmons Craig A, Yuen Darren A. Could MRI Be Used To Image Kidney Fibrosis? A Review of Recent Advances and Remaining Barriers. Clinical Journal of the American Society of Nephrology. 2017;12(6):1019-1028 | PubMed

30 Oct

Zhang Xiaoqing, Battiston Kyle G, Labow Rosalind S, Simmons Craig A,Santerre J Paul. Generating favorable growth factor and protease release profiles to enable extracellular matrix accumulation within an in vitro tissue engineering environment. Acta Biomaterialia. 2017;54:81-84 | PubMed

30 Oct

Wen Jun, Tao Hirotaka, Lau Kimberly, Liu Haijiao, Simmons Craig A, Sun Yu, Hopyan Sevan. Cell and Tissue Scale Forces Coregulate Fgfr2-Dependent Tetrads and Rosettes in the Mouse Embryo. Biophysical Journal. 2017;112(10):2209-2218. | PubMed

30 Oct

Zhang Xiaoqing, Bendeck Michelle P, Simmons Craig A, Santerre, J Paul. Deriving vascular smooth muscle cells from mesenchymal stromal cells: Evolving differentiation strategies and current understanding of their mechanisms. Biomaterials; 2017;145:9-22 | PubMed

30 Oct

Safaee Helia, Bakooshli Mohsen A, Davoudi Sadegh, Cheng, Richard Y, Martowirogo Aditya J, Li Edward W, Simmons Craig A, Gilbert, Penney M. Tethered Jagged-1 Synergizes with Culture Substrate Stiffness to Modulate Notch-Induced Myogenic Progenitor Differentiation. Cellular and molecular bioengineering. 2017;10(5):501-513. | SpringerLink

30 Oct

Usprech Jenna, Romero David A, Amon Cristina H, Simmons Craig A. Combinatorial screening of 3D biomaterial properties that promote myofibrogenesis for mesenchymal stromal cell-based heart valve tissue engineering. Acta Biomaterialia. 2017;58:34-43. | PubMed

18 Oct

Moraes C*, MacQueen LA*, Sun Y, Simmons CA. Microscale generation of dynamic forces in cell culture systems. In: Sun Y, Kim D-H, Simmons CA. (eds.) Integrative Mechanobiology: Micro and Nano Techniques in Cell Mechanobiology. Cambridge University Press, 2015. | Book Chapter

18 Oct

Battiston KG, Santerre JP, Simmons CA. Mechanobiological stimulation of engineered vascular tissues. In: Sun Y, Kim D-H, Simmons CA. (eds.) Integrative Mechanobiology: Micro and Nano Techniques in Cell Mechanobiology. Cambridge University Press, 2015. | Book Chapter

18 Oct

Blaser MC, Simmons CA. Mechanical and matrix regulation of fibrosis. In: Dixon IAC and Wigle J (eds.), Mechanisms of Cardiac Fibrosis and Heart Failure. Springer, 2015. | Book Chapter

18 Oct

Srigunapalan S, Simmons CA. Valvular endothelial mechanobiology. In: Aranda-Espinoza H (ed.), Mechanobiology of the Endothelium. CRC Press, 2015. | Book Chapter

18 Oct

MacQueen L, Moraes C, Sun Y, Simmons CA. Dynamic mechanical environments to quantify and control cellular dynamics. In: Cuerrier CM, Pelling AE (eds), Cells, Forces, and the Microenvironment. Pan Stanford Publishing, 2015. | Book Chapter

18 Oct

Blaser M, Simmons CA. Mechanobiology of cardiac and valvular fibrosis. In: Layton B (ed.), Molecular and Cellular Biomechanics. Pan Stanford Publishing, 2015. | Book Chapter

18 Oct

Moraes C, Sun Y, Simmons CA. Micro and nano-technologies for studies in cellular mechanics and mechanobiology. In: Gefen A (ed.), Cellular and Biomolecular Mechanics and Mechanobiology. Springer-Verlag, 2011. | Book Chapter

18 Oct

Chen WLK, Simmons CA. Mesenchymal stem cell mechanobiology. In: Nagatomi J (ed.), Mechanobiology Handbook. CRC Press, Boca Raton, 2011. | Book Chapter

18 Oct

Yip YYC*, Chen JH*, Simmons CA. Engineering substrate mechanics to regulate cell response. In: Khademhosseini et al. (eds.) Micro- and Nanoengineering of the Cell Microenvironment: Technologies and Applications. Artech House Publishing Inc., 2008. | Book Chapter

18 Oct

Simmons CA, Mooney DJ. Regulation of cellular response to mechanical signals by matrix design. In: Guilak, F. et al. (eds.) Functional Tissue Engineering. Springer-Verlag, Inc., New York, 2003. | Book Chapter

18 Oct

Pilliar RM, Simmons CA. Mechanical factors and osseointegration: Influence of implant design. In: Zarb, G. et al. (eds.) Aging, Osteoporosis and Dental Implants. Quintessence, Chicago, 2001. | Book chapter

18 Oct

Simmons CA, Pilliar RM. A biomechanical study of early tissue formation around bone-interfacing implants – The effect of implant surface geometry, In: Davies, J.E. (ed.) Bone Engineering. em squared, Inc., Toronto, 2001 | Book Chapter

21 Apr

Wong Jeremy F., Simmons Craig A., Young Edward W.K. Modeling and Measurement of Biomolecular Transport and Sensing in Microfluidic Cell Culture and Analysis Systems, In: Becker, S. (ed.)  Model. Microscale Transp. Biol. Process. 1st ed. 2017; Elsevier, pp. 41–75. | Book Chapter

27 Feb

Loai S, Haedicke I, Mirzaei Z, Simmons CA, Zhang XA, Cheng HL. Positive-contrast cellular MRI of embryonic stem cells for tissue regeneration using a highly efficient T1 MRI contrast agent. J Magn Reson Imaging, 2016; 44:1456-1463| PubMed

27 Feb

Niu CJ, Fisher C, Scheffler K, Wana R, Maleki H, Liu H, Sun Y, Simmons CA, Birngruber R, Lilge L. Polyacrylamide gel substrates that simulate the mechanical stiffness of normal and malignant neuronal tissues increase protoporphyin IX synthesis in glioma cells. Journal of Biomedical Optics, 2015;20:98002. | PubMed

27 Feb

Kheradvar A, Groves EM, Falahatpisheh A, Mofrad MK, Alavi SH, Tranquillo R, Dasi LP, Simmons CA, Grande-Allen KJ, Goergen CJ, Baaijens F,  Little SH, Canic S, Griffith B. Emerging trends in heart valve engineering: Part IV. Computational modeling and experimental studies. Ann Biomed Eng, 2015;43:2314-33. | PubMed

27 Feb

Battiston KG, Ouyang B, Honarparvar E, Qian J, Labow RS, Simmons CA, Santerre JP. Interaction of a block-co-polymeric biomaterial with immunoglobulin G modulates human monocytes towards a non-inflammatory phenotype. Acta Biomaterialia, 2015; 24:35-43. | PubMed

27 Feb

Battiston KG, Labow RS, Simmons CA, Santerre JP. Immunomodulatory polymeric scaffold enhances extracellular matrix production in cell co-cultures under dynamic mechanical stimulation. Acta Biomaterialia, 2015;24:74-86. | PubMed

27 Feb

Lau K, Tao H, Liu H, Wen J, Sturgeon K, Sorfazlian N, Lazic S, Burrows JTA, Wong M, Li D, Deimling S, Ciruna B, Scott I, Simmons CA, Henkelman RM, Williams T, Hadjantonakis AK, Fernandez-Gonzalez R, Sun Y, Hopyan S. Anisotropic stress orients remodelling of mammalian limb bud ectoderm. Nat Cell Biol, 2015;17:569–579. | PubMed

27 Feb

Kheradvar A, Groves EM, Dasi LP, Alavi SH, Tranquillo RT, Grande-Allen KJ, Simmons CA, Griffith BE, Falahatpisheh A, Goergen CJ, Mofrad MRK, Baaijens FPT, Little SH, Canic S. Emerging trends in heart valve engineering: Part I. Solutions for the future. Ann Biomed Eng, 2015;43:833-43. | PubMed

27 Feb

Kheradvar A, Groves EM, Goergen CJ, Alavi SH, Tranquillo RT, Simmons CA, Dasi LP, Grande-Allen KJ, Mofrad MRK, Falahatpisheh A, Griffith BE, Baaijens FPT, Little SH, Canic S. Emerging trends in heart valve engineering: Part II. Novel and standard technologies for aortic valve replacement. Ann Biomed Eng, 2015;43:844-57. | PubMed

27 Feb

Kheradvar A, Groves EM, Simmons CA, Griffith BE, Hamed Alavi S, Tranquillo RT, Dasi LP, Falahatpisheh A, Grande-Allen KJ, Goergen CJ, Mofrad MRK, Baaijens FPT, Canic S, Little SH. Emerging trends in heart valve engineering: Part III. Novel technologies for mitral valve repair and replacement. Ann Biomed Eng, 2015;43:858-70. | PubMed

07 Mar

Xiao Y, Zhang B, Liu H, Miklas JW, Gagliardi M, Pahnke A, Thavandiran N, Sun Y, Simmons CA, Keller G, Radisic M. Microfabricated perfusable cardiac biowire: a platform that mimics native cardiac bundle. Lab Chip, 2014;14:869-82. | Pubmed

01 Mar

Battiston KG, Ouyang B, Labow RS, Simmons CA, Santerre JP. Using monocytes/macrophages and their cytokine activity to promote vascular smooth muscle cell growth on a degradable polyurethane scaffold. Acta Biomaterialia, 2014;10:1146-55.| PubMed

03 Dec

Thavandiran N, Dubois N, Mikryukov A, Masse S, Beca B, Simmons CA, Deshpande V, McGarry P, Chen CS, Nanthakumar K, Keller G, Radisic M, Zandstra PW. Design and formulation of functional pluripotent stem cell-derived cardiac microtissues. Proc Natl Acad Sci U S A, 2013;110:E4698-707.| PubMed

07 Jul

Chen MB, Srigunapalan S, Wheeler AR, Simmons CA. A 3D microfluidic platform incorporating methacrylated gelatin hydrogels to study physiological cardiovascular cell–cell interactions. Lab Chip, 2013;13:2591-8.| PubMed

18 Oct

Rajamannan NM, Evans FJ, Aikawa E, Grande-Allen KJ, Demer LL, Heistad DD, Simmons CA, Masters KS, Mathieu P, O’Brien KD, Schoen FJ, Towler DA, Yoganathan AP, Otto CM. Calcific aortic valve disease: not simply a degenerative process: A review and agenda for research from the National Heart and Lung and Blood Institute Aortic Stenosis Working Group Executive Summary: Calcific aortic valve disease – 2011 update. Circulation,2011;124:1783-91.| PubMed

01 Jul

Sharifpoor S, Simmons CA, Labow RS, Paul Santerre J. Functional characterization of human coronary artery smooth muscle cells under cyclic mechanical strain in a degradable polyurethane scaffold. Biomaterials,2011;32:4816-4829.| PubMed

01 Nov

Sharifpoor S, Simmons CA, Labow RS, Santerre JP. A study of vascular smooth muscle cell function under cyclic mechanical loading in a degradable polyurethane scaffold with optimized porosity. Acta Biomaterialia, 2010;6:4218-4228. | PubMed

01 Jul

Yuen A, Laschinger C, Talior I, Lee W, Chan M, Birek J, Young EWK, Sivagurunathan K, Won E, Simmons CA, McCulloch CA. Methylglyoxal-modified collagen promotes myofibroblast differentiation. Matrix Biology, 2010;29:537-48. | PubMed

10 May

Moraes C, Wyss K, Brisson E, Keith BA, Sun Y, Simmons CA. An undergraduate lab (on-a-chip): Probing single cell mechanics on a microfluidic platform. Cellular and Molecular Bioengineering, 2010;3:319-330. | PubMed

01 May

Fiddes LK, Raz N, Srigunapalan S, Tumarkan E, Parkharenko V, Simmons CA, Wheeler AR, Kumacheva E. A circular cross-section PDMS microfluidics system for replication of cardiovascular flow conditions. Biomaterials,2010;31:3459-3464. | PubMed

01 Feb

Young EWK, Watson ML, Srigunapalan S, Wheeler AR, Simmons CA. Technique for real-time measurements of endothelial permeability in a microfluidic membrane chip using laser-induced fluorescence detection. Anal Chem,2010;82:808-816.| PubMed

01 Jan

Rask F*, Mihic A*, Reis L, Dallabrida SM, Ismail NS, Sider KL, Simmons CA, Rupnick MA, Weisel RD, Li R, Radisic M. Hydrogels modified with QHREDGS peptide support cardiomyocyte survival in vitro and after sub-cutaneous implantation. Soft Matter,2010;95:105-117.| PubMed

01 Jan

Young EWK, Simmons CA. “Student lab”-on-a-chip: Integrating low-cost microfluidics into undergraduate teaching labs to study multiphase flow phenomena in small vessels. Chem Eng Educ, 2009;43:232-240.| PubMed

01 Apr

Pho M, Lee W, Watt DR, Laschinger C, Simmons CA, McCulloch CA. Cofilin is a marker of myofibroblast differentiation in cells from porcine aortic cardiac valves. Am J Physiol Heart Circ, 2008;294:H1767-1778.| PubMed

16 Mar

Chong SA, Lee W, Arora PD, Laschinger C, Young EWK, Simmons CA, Manolson M, Sodek J, McCulloch CA. Methylglyoxal inhibits the binding step of collagen phagocytosis. J Biol Chem, 2007; 282:8510-8520.| PubMed

01 Mar

Huang YC, Simmons CA, Kaigler D, Rice KG, Mooney DJ. Bone regeneration in a rat cranial defect with delivery of PEI-condensed plasmid DNA encoding for bone morphogenetic protein-4 (BMP-4). Gene Ther, 2005;12:418-426.| PubMed

01 Oct

Simmons CA, Nikolovski J, Thornton AJ, Matlis S, Mooney DJ. Mechanical stimulation and mitogen-activated protein kinase signaling independently regulate osteogenic differentiation and mineralization by calcifying vascular cells. J Biomech,2004;37:1531-1541.| PubMed

01 Aug

Simmons CA, Alsberg E, Hsiong S, Kim WJ, Mooney DJ. Dual growth factor delivery and controlled scaffold degradation enhance in vivo bone formation by transplanted bone marrow stromal cells. Bone, 2004;35:562-569.| PubMed

01 Aug

Simmons CA, Matlis S, Thornton AJ, Chen S, Wang CY, Mooney DJ. Cyclic strain enhances matrix mineralization by adult human mesenchymal stem cells via the extracellular signal-regulated kinase (ERK1/2) signaling pathway. J Biomech,2003;36:1087-1096.| PubMed

01 Nov

Simmons CA, Valiquette N, Pilliar RM. Osseointegration of sintered porous-surfaced and plasma spray-coated implants: An animal model study of early postimplantation healing response and mechanical stability. J Biomed Mater Res, 1999;47:127-138.| PubMed