Mirani Bahram, Mathew Sean O, Latifi Neda, Labrosse Michel R, Amsden Brian G, Simmons Craig A. Programmable Melt Electrowriting to Engineer Soft Connective Tissues with Prescribed, Biomimetic, Biaxial Mechanical Properties. Advanced Functional Materials. 2023 | Wiley
Chung Jennifer C-Y, Eliathamby Daniella, Seo Hijun, Fan Chun-Po, Islam Rifat, Deol Karamvir, Simmons Craig A, Ouzounian Maral. Biomechanical properties of the aortic root are distinct from those of the ascending aorta in both normal and aneurysmal states. JTCVS Open. 2023 | Elsevier
Parvin Nejad Shouka, Lecce Monica, Mirani Bahram, Siquiera Nataly M., Mirzaei Zahra, Santerre J Paul., Davies John E., Simmons Craig A. Serum- and xeno-free culture of human umbilical cord perivascular cells for pediatric heart valve tissue engineering. Stem Cell Research & Therapy. 2023 | BioMed Central
Eliathamby Daniella, Keshishi Melanie, Ouzounian Maral, Forbes Thomas L., Tan Kongteng, Simmons Craig A., Chung Jennifer C-Y. Ascending aortic geometry and its relationship to the biomechanical properties of aortic tissue. JTCVS open. 2023 | Elsevier
Sebastian Joseph A., Strohm Eric M., Baranger Jerome., Villemain Olivier, Kolios Michael C., Simmons Craig A. Assessing engineered tissues and biomaterials using ultrasound imaging: In vitro and in vivo applications. Biomaterials. 2023 | Elsevier
Sebastian Joseph A., Strohm Eric M., Chérin Emmanuel, Mirani Bahram, Démoré Christine, Kolios Michael C., Simmons Craig A. High-frequency quantitative ultrasound for the assessment of the acoustic properties of engineered tissues in vitro. Acta Biomaterialia. 2022 | Elsevier
Eliathamby Daniella, Keshishi Melanie, Ouzounian Maral, Forbes Thomas L., Tan Kongteng, Simmons Craig A., Chung Jennifer. Ascending aortic geometry and its relationship to the biomechanical properties of aortic tissue. JTCVS Open. 2022. Elsevier
Bergevin Michele d., Boczula Anna E., Caruso Laura-lee., Persson Henrik., Simmons Craig A., Moriarty Tara J. A live cell imaging microfluidic model for studying extravasation of bloodborne bacterial pathogens. 2022. Cellular Microbiology. Wiley
Callaghan Neal I., Durland Lauren J., Ireland Ronald G., Santerre J. Paul, Simmons Craig A. Harnessing conserved signaling and metabolic pathways to enhance the maturation of functional engineered tissues. npj Regenerative Medicine. 2022 | Springer Nature
Sefton Michael V, Simmons Craig A. Hearts by design. Science | AAAS
Dou Wenkun, Malhi Manpreet, Cui Teng, Wang Minyao, Wang Tiancong, Shan Guanqiao, Law Junhui, Gong Zheyuan, Plakhotnik Julia, Filleter Tobin, Li Renke, Simmons Craig A., Maynes Jason T., Sun Yu. A carbon-based biosensing platform for simultaneously measuring the contraction and electrophysiology of iPSC-cardiomyocyte monolayers. ACS Nano. 2022 | American Chemical Society
Wong Edwin KY., Parvin Nejad Shouka, D’Costa Katya A., Machado Siqueira Nataly, Lecce Monica, Santerre Paul, Simmons Craig A. Design of a mechanobioreactor to apply anisotropic, biaxial strain to large thin biomaterials for tissue engineered heart valve applications. Annals of Biomedical Engineering. 2022 | Springer
Nouri Shahrzad, Holcroft James, Caruso Laura-lee, Vuong Thu V., Simmons Craig A., Master Emma R., Ganss Berhnhard. An SCPPPQ1/LAM332 protein complex enhances the adhesion and migration of oral epithelial cells: Implications for dentogingival regeneration. 2022 | Elsevier.
Dou Wenkun, Malhi Manpreet, Zhao Qili, Wang Li, Huang Zongjie, Law Junhui, Liu Na, Simmons Craig A., Maynes Jason T., Sun Yu. Microengineered platforms for characterizing the contractile function of in vitro cardiac models. 2022 | Springer Nature
Persson Henrik, Park Siwan, Mohan Michael, Cheung Ka Kit, Simmons Craig A., Young Edmond WK. Rapid assembly of PMMA microfluidic devices with PETE membranes for studying the endothelium. Sensors and Actuators B: Chemical. 2021 | Elsevier
McClarty Davis, Ouzounian Maral, Tang Mingyi, Eliathamby Daniella, Romero David, Nguyen Elsie, Simmons Craig A., Amon Cristina, Chung Jennifer C-Y. Ascending aortic aneurysm haemodynamics are associated with aortic wall biomechanical properties. European Journal of Cardio-Thoracic Surgery. 2021 | Oxford Academic
Anthonyshyn Jeremy A., Mazzoli Vienna, McFadden Meghan J., Gramolini Anthony O., Hofer Stefan O. P., Simmons Craig A., Santerre, Paul. Mitigating the non-specific uptake of immunomagnetic microparticles enables the extraction of endothelium from human fat. Communications Biology. 2021 | Nature Publishing Group
Tang Mingyi, Eliathamby Daniella, Ouzounian Maral, Simmons Craig A, Chung Jennifer C.-Y. Dependency of energy loss on strain rate, strain magnitude and preload: Towards development of a novel biomarker for aortic aneurysm dissection risk. Journal of the Mechanical Behavior of Biomedical Materials. 2021 | Elsevier
Liu Haijao, Usprech Jenna F., Parameshwar Prabu K., Sun Yu, Simmons Craig A. Combinatorial screen of dynamic mechanical stimuli for predictive control of MSC mechano-responsiveness. Science Advances. 2021 | AAAS
Mirani Bahram, Parvin Nejad Shouka, Simmons Craig A. Recent progress toward clinical translation of tissue engineered heart valves. Canadian Journal of Cardiology. 2021 | Elsevier
Dou Wenkun, Wang Li, Malhi Manpreet, Liu Haijao, Zhao Qili, Plakhotnik Julia, Xu Zhensong, Huang Zongjie, Simmons Craig A., Maynes Jason T., Sun Yu. A microdevice platform for characterizing the effect of mechanical strain magnitudes on the maturation of iPSC-Cardiomyocytes. Biosensors and Bioelectronics. 2021 | Elsevier
Simmons Craig A., Ireland Ronald G. Stretch-boosted cell-mediation vascularization. Nature Biomedical Engineering. 2021 | Nature Publishing Group.
Latifi Neda, Lecce Monica, Simmons Craig A. Porcine umbilical cord perivascular cells for preclinical testing of tissue engineered heart valves. Tissue Engineering Part C: Methods. 2020 | Mary Ann Liebert, Inc.
Maleki Hoda, Doyle Matthew G., Chehade Moussa, Liu Qian, Simmons Craig A. The focal mechanical properties of normal and diseased porcine aortic valve tissue measured by a novel microindentation device. Journal of the Mechanical Behavior of Biomedical Materials. 2020 | Elsevier.
Dou Wenkun, Wang Li, Malhi Manpreet, Liu Haijao, Zhao Qili, Plakhotnik Julia, Xu Zhensong, Huang Zongjie, Simmons Craig A., Maynes Jason T., Sun Yu. A microdevice platform for characterizing the effect of mechanical strain magnitudes on the maturation of iPSC-Cardiomyocytes. Biosensors and Bioelectronics. 2020 | Elsevier
Fitzsimmons Ross E.B., Ireland Ronald G., Zhong Aileen., Soos Agnes, Simmons Craig A., Assessment of fibrin-collagen co-gels for generating microvessels ex vivo using endothelial cell-lined microfluidics and multipotent stromal cell (MSC)-induced capillary morphogenesis. Biomedical Materials. 2020 | IOP Science.
Chung Jennifer C-Y., Wong Edwin, Tang Mingyi, Eliathamby Daniella, Forbes Thomas L., Butany Jagdish, Simmons Craig A., Ouzounian Maral, Biomechanics of Aortic Dissection: A Comparison of Aortas Associated With Bicuspid and Tricuspid Aortic Valves. Journal of the American Heart Association. 2020 | Wiley
Callaghan Neal I., Lee Shin-Haw, Hadipour-Lakmehsari Sina, Lee Xavier A., Siraj M. Ahsan, Driouchi Amine, Yip Christopher M., Husain Mansoor,Simmons Craig A., Gramolini Anthony O., Functional culture and in vitro genetic and small-molecule manipulation of adult mouse cardiomyocytes. Communications Biology. 2020 | Nature Publishing Group
Ireland Ronald G., Kibschull Mark, Audet Julie, Ezzo Maya, Hinz Boris, Lye Stephen J., Simmons Craig A., Combinatorial extracellular matrix microarray identifies novel bioengineered substrates for xeno-free culture of human pluripotent stem cells. Biomaterials. 2020 | Elsevier
Miranda Maria Z., Turki Razan, Kuebler Wolfgang M., Simmons Craig A., Kapus Andras, Regulation of TAZ Expression by Cyclic Stretch. The FASEB Journal. 2020 | Wiley
Gellner Bryan, Xin Liming, Ribeiro Roberto V.P., Bissoondath Ved, Lu Pengzhoi, Adamson Mitchell B., Yu Frank, Paradiso Emanuela, Zu Jean, Simmons Craig A., Badiwala Mitesh V., The implementation of an adjustable afterload module during ex situ heart perfusion. Cardiovascular Engineering and Technology. 2020 | Springer
Gellner Bryan, Xin Liming, Ribeiro Roberto V.P., Bissoondath Ved, Adamson Mitchell B., Yu Frank, Lu Pengzhou, Paradiso Emanuela, Hondjeu Arnaud R.M., Simmons Craig A., Badiwala Mitesh V., The implementation of physiological afterload during ex situ heart perfusion augments prediction of posttransplant function. American Journal of Physiology – Heart and Circulatory Physiology. 2020 | American Physiological Society
Wong Jeremy F., Mohan Michael D., Young Edmond W.K., Simmons Craig A., Integrated electrochemical measurement of endothelial permeability in a 3D hydrogel-based microfluidic vascular model. Biosensors and Bioelectronics. 2020 | Elsevier
Hadipour-Lakmehsari Sina, Driouchi Amine, Lee Shin-Haw, Kuzmanov Uros, Callaghan Neal I., Heximer Scott P., Simmons Craig A., Yip Christopher M., Gramolini Anthony O., Nanoscale reorganization of sarcoplasmic reticulum in pressure-overload cardiac hypertrophy visualized by dSTORM. Scientific Reports. 2019 | Nature Publishing Group
Callaghan Neal, Hadipour-Lakmehsari Sina, Lee Shin-Haw, Gramolini Anthony O., Simmons Craig A., Modeling cardiac complexity: Advancements in myocardial models and analytical techniques for physiological investigation and therapeutic development in vitro. APL Bioengineering. 2019 | AIP
Wong Jeremy, Simmons Craig A. Microfluidic assay for the on-chip electrochemical measurement of cell monolayer permeability. Lab on a chip. 2019 | RSC
Lam Alan Y, Simmons Craig A., Cell and Extracellular Matrix Interactions in a Dynamic Biomechanical Environment: The Aortic Valve as an Illustrative Example. In: Labrosse MR, eds. Cardiovascular Mechanics. Boca Raton, FL: CRC Press; 2018. | Book Chapter
Fitzsimmons Ross E. B, Mazurek Matthew S, Soos Agnes, Simmons Craig A. Mesenchymal Stromal/Stem Cells in Regenerative Medicine and Tissue Engineering. Stem Cells International. 2018 | Hindawi
Fitzsimmons Ross EB, Aquilino Mark S., Quigley Jasmine, Chebotarev Oleg, Tarlan Farhang, Simmons Craig A. Generating vascular channels within hydrogel constructs using an economical open-source 3D bioprinter and thermoreversible gels. Bioprinting: 2018; 9:7-18 | ScienceDirect
Liu Haijiao, MacQueen Luke A., Usprech Jenna F., Maleki Hoda, Sider Krista L., Doyle Matthew G., Sun Yu, Simmons Craig A. Microdevice arrays with strain sensors for 3D mechanical stimulation and monitoring of engineered tissues. Biomaterials. 2018;172:30-40 |ScienceDirect
Zhong, Aileen, Mirzaei, Zahra, Simmons, Craig A. The Roles of Matrix Stiffness and ß-Catenin Signaling in Endothelial-to- Mesenchymal Transition of Aortic Valve Endothelial Cells. Cardiovascular Engineering and Technology. 2018;9:158-167|Springer
Blaser MC, Wei K, Adams RLE, Zhou YQ, Caruso LL, Mirzaei Z, Lam AY, Tam RKK, Zhang H, Heximer SP, Henkelman RM, Simmons CA. Deficiency of Natriuretic Peptide Receptor 2 Promotes Bicuspid Aortic Valves, Aortic Valve Disease, Left Ventricular Dysfunction, and Ascending Aortic Dilatations in Mice. Circulation Research. 2018; 2(122): 405-416 | PubMed
Wong F. Jeremy, Young Edmond W.K, Simmons, Craig A. Computational analysis of integrated biosensing and shear flow in a microfluidic vascular model. AIP Advances. 2017; 7: 115116 | AIP
Zhang Xiaoqing, Battiston Kyle, Simmons Craig A, Santerre J Paul. Differential regulation of extracellular matrix components by using different vitamin C derivatives in mono-and co-culture systems. ACS Biomaterials Science & Engineering. 2017 | ACS
Leung General, Kirpalani Anish, Szeto Stephen G, Deeb Maya, Warren Foltz, Simmons Craig A, Yuen Darren A. Could MRI Be Used To Image Kidney Fibrosis? A Review of Recent Advances and Remaining Barriers. Clinical Journal of the American Society of Nephrology. 2017;12(6):1019-1028 | PubMed
Zhang Xiaoqing, Battiston Kyle G, Labow Rosalind S, Simmons Craig A,Santerre J Paul. Generating favorable growth factor and protease release profiles to enable extracellular matrix accumulation within an in vitro tissue engineering environment. Acta Biomaterialia. 2017;54:81-84 | PubMed
Wen Jun, Tao Hirotaka, Lau Kimberly, Liu Haijiao, Simmons Craig A, Sun Yu, Hopyan Sevan. Cell and Tissue Scale Forces Coregulate Fgfr2-Dependent Tetrads and Rosettes in the Mouse Embryo. Biophysical Journal. 2017;112(10):2209-2218. | PubMed
Zhang Xiaoqing, Bendeck Michelle P, Simmons Craig A, Santerre, J Paul. Deriving vascular smooth muscle cells from mesenchymal stromal cells: Evolving differentiation strategies and current understanding of their mechanisms. Biomaterials; 2017;145:9-22 | PubMed
Safaee Helia, Bakooshli Mohsen A, Davoudi Sadegh, Cheng, Richard Y, Martowirogo Aditya J, Li Edward W, Simmons Craig A, Gilbert, Penney M. Tethered Jagged-1 Synergizes with Culture Substrate Stiffness to Modulate Notch-Induced Myogenic Progenitor Differentiation. Cellular and molecular bioengineering. 2017;10(5):501-513. | SpringerLink
Usprech Jenna, Romero David A, Amon Cristina H, Simmons Craig A. Combinatorial screening of 3D biomaterial properties that promote myofibrogenesis for mesenchymal stromal cell-based heart valve tissue engineering. Acta Biomaterialia. 2017;58:34-43. | PubMed
Ethier CR, Simmons CA. Biomechanics: From cells to organisms. Cambridge University Press, New York, 2007. | Textbook
Sun Y, Kim D-H, Simmons CA. (eds.) Integrative Mechanobiology: Micro and Nano Techniques in Cell Mechanobiology. Cambridge University Press, 2015. | Edited Book
Zhong A, Simmons CA. Heart valve mechanobiology in development and disease. In: Chien S, Engler AJ, Wang Y (eds.) Molecular and Cellular Mechanobiology. American Physiological Society, 2016. | Book Chapter
Moraes C*, MacQueen LA*, Sun Y, Simmons CA. Microscale generation of dynamic forces in cell culture systems. In: Sun Y, Kim D-H, Simmons CA. (eds.) Integrative Mechanobiology: Micro and Nano Techniques in Cell Mechanobiology. Cambridge University Press, 2015. | Book Chapter
Battiston KG, Santerre JP, Simmons CA. Mechanobiological stimulation of engineered vascular tissues. In: Sun Y, Kim D-H, Simmons CA. (eds.) Integrative Mechanobiology: Micro and Nano Techniques in Cell Mechanobiology. Cambridge University Press, 2015. | Book Chapter
Blaser MC, Simmons CA. Mechanical and matrix regulation of fibrosis. In: Dixon IAC and Wigle J (eds.), Mechanisms of Cardiac Fibrosis and Heart Failure. Springer, 2015. | Book Chapter
Srigunapalan S, Simmons CA. Valvular endothelial mechanobiology. In: Aranda-Espinoza H (ed.), Mechanobiology of the Endothelium. CRC Press, 2015. | Book Chapter
MacQueen L, Moraes C, Sun Y, Simmons CA. Dynamic mechanical environments to quantify and control cellular dynamics. In: Cuerrier CM, Pelling AE (eds), Cells, Forces, and the Microenvironment. Pan Stanford Publishing, 2015. | Book Chapter
Blaser M, Simmons CA. Mechanobiology of cardiac and valvular fibrosis. In: Layton B (ed.), Molecular and Cellular Biomechanics. Pan Stanford Publishing, 2015. | Book Chapter
Liu J*, Moraes C*, Lu Z, Simmons CA, Sun Y. Single cell deposition. In: Methods Cell Biol, 2012: 112:403-420. | Book Chapter
Moraes C, Sun Y, Simmons CA. Micro and nano-technologies for studies in cellular mechanics and mechanobiology. In: Gefen A (ed.), Cellular and Biomolecular Mechanics and Mechanobiology. Springer-Verlag, 2011. | Book Chapter
Chen WLK, Simmons CA. Mesenchymal stem cell mechanobiology. In: Nagatomi J (ed.), Mechanobiology Handbook. CRC Press, Boca Raton, 2011. | Book Chapter
Yip YYC*, Chen JH*, Simmons CA. Engineering substrate mechanics to regulate cell response. In: Khademhosseini et al. (eds.) Micro- and Nanoengineering of the Cell Microenvironment: Technologies and Applications. Artech House Publishing Inc., 2008. | Book Chapter
Simmons CA, Mooney DJ. Regulation of cellular response to mechanical signals by matrix design. In: Guilak, F. et al. (eds.) Functional Tissue Engineering. Springer-Verlag, Inc., New York, 2003. | Book Chapter
Pilliar RM, Simmons CA. Mechanical factors and osseointegration: Influence of implant design. In: Zarb, G. et al. (eds.) Aging, Osteoporosis and Dental Implants. Quintessence, Chicago, 2001. | Book chapter
Simmons CA, Pilliar RM. A biomechanical study of early tissue formation around bone-interfacing implants – The effect of implant surface geometry, In: Davies, J.E. (ed.) Bone Engineering. em squared, Inc., Toronto, 2001 | Book Chapter
Wong Jeremy F., Simmons Craig A., Young Edward W.K. Modeling and Measurement of Biomolecular Transport and Sensing in Microfluidic Cell Culture and Analysis Systems, In: Becker, S. (ed.) Model. Microscale Transp. Biol. Process. 1st ed. 2017; Elsevier, pp. 41–75. | Book Chapter
Ebady R, Niddam AF, Boczula AE, Kim YR, Gupta N, Tang TT, Odisho T, Zhi H, Simmons CA, Skare JT, Moriarty TJ. Biomechanics of Borrelia burgdorferi vascular interactions. Cell Rep. 2016;16(10):2593-604. | PubMed
Loai S, Haedicke I, Mirzaei Z, Simmons CA, Zhang XA, Cheng HL. Positive-contrast cellular MRI of embryonic stem cells for tissue regeneration using a highly efficient T1 MRI contrast agent. J Magn Reson Imaging, 2016; 44:1456-1463| PubMed
Usprech J, Chen WLK, Simmons CA. Heart valve regeneration: The need for systems approaches. WIRE Systems Biology and Medicine, 2016; 8:169-82. | PubMed
Liu Haijiao, Usprech Jenna, Sun Yu, Simmons Craig A. A microfabricated platform with hydrogel arrays for 3D mechanical stimulation of cells. Acta Biomaterialia, 2016; 34:113-24. | PubMed
Parvin Nejad S, Blaser MC, Santerre JPS, Caldarone CA, Simmons CA. Biomechanical conditioning of tissue engineered heart valves: Too much of a good thing? Advanced Drug Delivery Reviews, 2016;96:161-75. | PubMed
Ireland R, Simmons CA. Pluripotent stem cell mechanobiology. Stem Cells (invited review), 2015;33:3187-96. | PubMed
Niu CJ, Fisher C, Scheffler K, Wana R, Maleki H, Liu H, Sun Y, Simmons CA, Birngruber R, Lilge L. Polyacrylamide gel substrates that simulate the mechanical stiffness of normal and malignant neuronal tissues increase protoporphyin IX synthesis in glioma cells. Journal of Biomedical Optics, 2015;20:98002. | PubMed
Kheradvar A, Groves EM, Falahatpisheh A, Mofrad MK, Alavi SH, Tranquillo R, Dasi LP, Simmons CA, Grande-Allen KJ, Goergen CJ, Baaijens F, Little SH, Canic S, Griffith B. Emerging trends in heart valve engineering: Part IV. Computational modeling and experimental studies. Ann Biomed Eng, 2015;43:2314-33. | PubMed
Plaza GR, Uyeda TQP, Mirzaei Z, Simmons CA. Study of the influence of actin-binding proteins using linear analyses of cell deformability. Soft Matter, 2015;11:5435-46. | PubMed
Battiston KG, Ouyang B, Honarparvar E, Qian J, Labow RS, Simmons CA, Santerre JP. Interaction of a block-co-polymeric biomaterial with immunoglobulin G modulates human monocytes towards a non-inflammatory phenotype. Acta Biomaterialia, 2015; 24:35-43. | PubMed
Battiston KG, Labow RS, Simmons CA, Santerre JP. Immunomodulatory polymeric scaffold enhances extracellular matrix production in cell co-cultures under dynamic mechanical stimulation. Acta Biomaterialia, 2015;24:74-86. | PubMed
Lau K, Tao H, Liu H, Wen J, Sturgeon K, Sorfazlian N, Lazic S, Burrows JTA, Wong M, Li D, Deimling S, Ciruna B, Scott I, Simmons CA, Henkelman RM, Williams T, Hadjantonakis AK, Fernandez-Gonzalez R, Sun Y, Hopyan S. Anisotropic stress orients remodelling of mammalian limb bud ectoderm. Nat Cell Biol, 2015;17:569–579. | PubMed
Kheradvar A, Groves EM, Dasi LP, Alavi SH, Tranquillo RT, Grande-Allen KJ, Simmons CA, Griffith BE, Falahatpisheh A, Goergen CJ, Mofrad MRK, Baaijens FPT, Little SH, Canic S. Emerging trends in heart valve engineering: Part I. Solutions for the future. Ann Biomed Eng, 2015;43:833-43. | PubMed
Kheradvar A, Groves EM, Goergen CJ, Alavi SH, Tranquillo RT, Simmons CA, Dasi LP, Grande-Allen KJ, Mofrad MRK, Falahatpisheh A, Griffith BE, Baaijens FPT, Little SH, Canic S. Emerging trends in heart valve engineering: Part II. Novel and standard technologies for aortic valve replacement. Ann Biomed Eng, 2015;43:844-57. | PubMed
Kheradvar A, Groves EM, Simmons CA, Griffith BE, Hamed Alavi S, Tranquillo RT, Dasi LP, Falahatpisheh A, Grande-Allen KJ, Goergen CJ, Mofrad MRK, Baaijens FPT, Canic S, Little SH. Emerging trends in heart valve engineering: Part III. Novel technologies for mitral valve repair and replacement. Ann Biomed Eng, 2015;43:858-70. | PubMed
Mohammadi H, Arora PD, Simmons CA, Janmey PA, McCulloch CA. Inelastic behaviour of collagen networks in cell-matrix interactions and mechanosensation. J R Soc Interface, 2015;12:20141074 | PubMed
Battiston KG, Ouyang B, Labow RS, Simmons CA, Santerre JP. Using monocytes/macrophages and their cytokine activity to promote vascular smooth muscle cell growth on a degradable polyurethane scaffold. Acta Biomaterialia, 2014;10:1146-55. | PubMed
Sider KL, Zhu C, Kwong AV, Mirzaei Z, De Lange CFM, Simmons CA. Evaluation of a porcine model of early aortic valve sclerosis. Cardiovasc Pathol, 2014;23:289-97.| PubMed
Liu H, Wen J, Xiao Y, Liu J, Hopyan S, Radisic M, Simmons CA#, Sun Y#. In situ mechanical characterization of the cell nucleus by atomic force microscopy. ACS Nano, 2014;8:3821-8.| PubMed
Xiao Y, Zhang B, Liu H, Miklas JW, Gagliardi M, Pahnke A, Thavandiran N, Sun Y, Simmons CA, Keller G, Radisic M. Microfabricated perfusable cardiac biowire: a platform that mimics native cardiac bundle. Lab Chip, 2014;14:869-82. | Pubmed
Liu H, Tan Q, Geddie WR, Jewett MAS, Phillips N, Ke D, Simmons CA, Sun Y. Biophysical characterization of bladder cancer cells with different metastatic potential. Cell Biochem Biophys, 2014; 68:241-97.| PubMed
Battiston KG, Ouyang B, Labow RS, Simmons CA, Santerre JP. Using monocytes/macrophages and their cytokine activity to promote vascular smooth muscle cell growth on a degradable polyurethane scaffold. Acta Biomaterialia, 2014;10:1146-55.| PubMed
Thavandiran N, Dubois N, Mikryukov A, Masse S, Beca B, Simmons CA, Deshpande V, McGarry P, Chen CS, Nanthakumar K, Keller G, Radisic M, Zandstra PW. Design and formulation of functional pluripotent stem cell-derived cardiac microtissues. Proc Natl Acad Sci U S A, 2013;110:E4698-707.| PubMed
Zhao R, Simmons CA. A simple method to estimate the exponential material parameters of heart valve tissue based on analogy between uniaxial tension and micropipette aspiration. Biomech Model Mechanobiol, 2013;12:1283-90.| PubMed
Heckler AF, Mirzaei Z, Pereira I, Simmons CA, Gong S-G. Development of a three-dimensional in vitro model system to study orthodontic tooth movement. Arch Oral Biol, 2013;58:1498-1510.| PubMed
Liu H, Sun Y, Simmons CA. Determination of local and global elastic moduli of valve interstitial cells cultured on soft substrates. J Biomech, 2013;46:1967-71.| PubMed
Chen MB, Srigunapalan S, Wheeler AR, Simmons CA. A 3D microfluidic platform incorporating methacrylated gelatin hydrogels to study physiological cardiovascular cell–cell interactions. Lab Chip, 2013;13:2591-8.| PubMed
Gould ST, Srigunapalan S, Simmons CA, Anseth KS. Hemodynamic and cellular response feedback in calcific aortic valve disease. Circ Res, 2013;113:186-97.| PubMed
Macqueen L, Sun Y, Simmons CA. Mesenchymal stem cell mechanobiology and emerging experimental platforms. J R Soc Interface, 2013;10:20130179.| PubMed
Moraes C*, Likhitpanichkul M*, Lam CJ, Beca BM, Sun Y, Simmons CA. Microdevice array-based identification of distinct mechanobiological response profiles in layer-specific valve interstitial cells. Integr Biol, 2013;5:673-80.| PubMed
MacQueen L, Chebotarev O, Simmons CA#, Sun Y#. Miniaturized platform with on-chip strain sensors for compression testing of arrayed materials. Lab Chip, 2012;12:4178-84.| PubMed
Al-Haque S, Miklas JW, Feric N, Chiu LL, Chen WL, Simmons CA, Radisic M. Hydrogel substrate stiffness and topography interact to induce contact guidance in cardiac fibroblasts. Macromol Biosci, 2012;12:1342-53.| PubMed
Wyss K, Yip CYY, Mirzaei Z, Jin X, Chen JH, Simmons CA. The elastic properties of valve interstitial cells undergoing pathological differentiation. J Biomech, 2012;45:882-887. Supplemental material.| PubMed
Srigunapalan S*, Eydelnant IA*, Simmons CA, Wheeler AR. A digital microfluidic platform for primary cell culture and analysis. Lab Chip, 2012;12:369-75. | PubMed
Zhao R, Simmons CA. An improved texture correlation algorithm to measure substrate-cytoskeletal network strain transfer under large compressive strain. J Biomech, 2012;45:76-82.| PubMed
Cheung WY, Simmons CA#, You L#. Osteocyte apoptosis regulates osteoclast precursor adhesion via osteocytic IL-6 secretion and endothelial ICAM-1 expression. Bone, 2012;50:104-110.| PubMed
Liu J*, Moraes C*, Lu Z, Simmons CA, Sun Y. Single cell deposition. Methods Cell Biol, 2012;112:403-420.| PubMed
Rajamannan NM, Evans FJ, Aikawa E, Grande-Allen KJ, Demer LL, Heistad DD, Simmons CA, Masters KS, Mathieu P, O’Brien KD, Schoen FJ, Towler DA, Yoganathan AP, Otto CM. Calcific aortic valve disease: not simply a degenerative process: A review and agenda for research from the National Heart and Lung and Blood Institute Aortic Stenosis Working Group Executive Summary: Calcific aortic valve disease – 2011 update. Circulation,2011;124:1783-91.| PubMed
Moraes C, Sun Y#, Simmons CA#. (Micro) managing the mechanical microenvironment. Integr Biol, 2011;3:959-971.| PubMed
Young EWK, Wheeler AR, Simmons CA. Avoiding bubble injection by droplet merging. Chips & Tips (online supplement to Lab on a Chip), Oct. 23, 2006. | PubMed
Yip CY, Blaser MC, Mirzaei Z, Zhong X, Simmons CA. Inhibition of pathological differentiation of valve interstitial cells by C-type natriuretic peptide. Arterioscler Thromb Vasc Biol, 2011;31:1881-1889. Supplemental material| PubMed
Sharifpoor S, Simmons CA, Labow RS, Paul Santerre J. Functional characterization of human coronary artery smooth muscle cells under cyclic mechanical strain in a degradable polyurethane scaffold. Biomaterials,2011;32:4816-4829.| PubMed
Chen JH, Simmons CA. Cell–matrix interactions in the pathobiology of calcific aortic valve disease. Circ Res,2011;108:1510-1524.| PubMed
Yip CYY, Simmons CA. The aortic valve microenvironment and its role in calcific aortic valve disease.Cardiovascular Pathology,2011;20:177-182.| PubMed
Chen WLK, Simmons CA. Lessons from (patho)physiological tissue stiffness and their implications for drug screening, drug delivery and regenerative medicine. Advanced Drug Delivery Reviews, 2011;63:269-276.| PubMed
Cheung WY, Liu C, Tonelli-Zasarsky RML, Simmons CA#, You L#. Osteocyte apoptosis is mechanically regulated and induces angiogenesis in vitro. J Orthop Res, 2011;29:523-530.| PubMed
Srigunapalan S, Lam C, Wheeler AR, Simmons CA. A microfluidic membrane device to mimic critical components of the vascular microenvironment. Biomicrofluidics, 2011;5:13409.| PubMed
Zhao R*, Sider KL*, Simmons CA. Measurement of layer-specific mechanical properties in multilayered biomaterials by micropipette aspiration. Acta Biomaterialia, 2011;7:1220-1227.| PubMed
Chen JH, Chen WLK, Sider KL, Yip CYY and Simmons CA. β-catenin mediates mechanically regulated, transforming growth factor-β1 induced myofibroblast differentiation of aortic valve interstitial cells. Arterioscler Thromb Vasc Biol, 2011;31:590-597.Supplemental material / Commentary| PubMed
Sider KL*, Blaser MC*, Simmons CA. Animal models of calcific aortic valve disease. Int J Inflam, 2011; 364310.| PubMed
Moraes C, Zhao R, Likhitpanichkul M, Simmons CA#, Sun Y#. Semi-confined compression of microfabricated polymerized biomaterial constructs. J Micromech Microeng, 2011;21.| PubMed
Moraes C, Sun Y, Simmons CA. Microfabricated platforms for mechanically dynamic cell culture. J Visualized Experiments,2010; http://www.jove.com/index/Details.stp?ID=2224, 2224.| PubMed
Sharifpoor S, Simmons CA, Labow RS, Santerre JP. A study of vascular smooth muscle cell function under cyclic mechanical loading in a degradable polyurethane scaffold with optimized porosity. Acta Biomaterialia, 2010;6:4218-4228. | PubMed
Lu Z*, Moraes C*, Ye G, Simmons CA, Sun Y. Single cell deposition and patterning with a robotic system. PLoS One,2010;5:e13542.| PubMed
Eilaghi A, Flanagan JG, Tertinegg I, Simmons CA, Brodland GW, Ethier CR. Biaxial mechanical testing of human sclera. J Biomech, 2010;43:1696-1701. | PubMed
Yuen A, Laschinger C, Talior I, Lee W, Chan M, Birek J, Young EWK, Sivagurunathan K, Won E, Simmons CA, McCulloch CA. Methylglyoxal-modified collagen promotes myofibroblast differentiation. Matrix Biology, 2010;29:537-48. | PubMed
Moraes C, Sun Y, Simmons CA. Chips & Tips: Connector-less manipulation of small liquid volumes in microchannels. www.rsc.org/Publishing/Journals/lc/microchannels.asp, Lab Chip, June 11, 2010.| PubMed
Moraes C, Wyss K, Brisson E, Keith BA, Sun Y, Simmons CA. An undergraduate lab (on-a-chip): Probing single cell mechanics on a microfluidic platform. Cellular and Molecular Bioengineering, 2010;3:319-330. | PubMed
Fiddes LK, Raz N, Srigunapalan S, Tumarkan E, Parkharenko V, Simmons CA, Wheeler AR, Kumacheva E. A circular cross-section PDMS microfluidics system for replication of cardiovascular flow conditions. Biomaterials,2010;31:3459-3464. | PubMed
Bhana B, Iyer RK, Chen WL, Zhao R, Sider KL, Likhitpanichkul M, Simmons CA, Radisic M. Influence of substrate stiffness on the phenotype of heart cells. Biotechnol Bioeng, 2010;105:1148-1160. Journal cover| PubMed
Eilaghi A, Flanagan JG, Simmons CA, Ethier CR. Effects of scleral stiffness properties on optic nerve head biomechanics. Ann Biomed Eng, 2010;38:1586-1592. | PubMed
Chen WLK, Likhitpanichkul M, Ho A, Simmons CA. Integration of statistical modeling and high-content microscopy to systematically investigate cell-substrate interactions. Biomaterials, 2010;31:2489-2497.| PubMed
Young EWK, Watson ML, Srigunapalan S, Wheeler AR, Simmons CA. Technique for real-time measurements of endothelial permeability in a microfluidic membrane chip using laser-induced fluorescence detection. Anal Chem,2010;82:808-816.| PubMed
Young EWK, Simmons CA. Macro- and microscale fluid flow systems for endothelial cell biology. LabChip,2010;10:143-160. Journal cover. | PubMed
Moraes C, Chen J-H, Sun Y, Simmons CA. Microfabricated arrays for high-throughput screening of cellular response to cyclic substrate deformation. LabChip, 2010;10:227-234. | PubMed
Chen JH, Liu C, You L, Simmons CA. Boning up on Wolff’s Law: Mechanical regulation of the cells that make and maintain bone. J Biomech, 2010;43:108-118.| PubMed
Moraes C, Wang GH, Sun Y, Simmons CA. A microfabricated platform for high-throughput unconfined compression of micropatterned biomaterial arrays. Biomaterials, 2010;31:577-584.| PubMed
Rask F*, Mihic A*, Reis L, Dallabrida SM, Ismail NS, Sider KL, Simmons CA, Rupnick MA, Weisel RD, Li R, Radisic M. Hydrogels modified with QHREDGS peptide support cardiomyocyte survival in vitro and after sub-cutaneous implantation. Soft Matter,2010;95:105-117.| PubMed
Zhao R, Wyss K, Simmons CA. Comparison of analytical and inverse finite element approaches to estimate cell viscoelastic properties by micropipette aspiration. J Biomech, 2009;42:2768-2773. Supplemental material| PubMed
Brooks PJ, Nilforoushan D, Manolson MF, Simmons CA, Gong S-G. Molecular markers of early orthodontic tooth movement.Angle Orthod, 2009; 79:1108-1113.| PubMed
Moraes C, Kagoma YK, Beca BM, Tonelli-Zasarsky RLM, Sun Y, Simmons CA. Integrating polyurethane culture substrates into multilayer poly(dimethylsiloxane) microdevices. Biomaterials, 2009;30:5241-5250.| PubMed
Yip CY, Chen JH, Zhao R, Simmons CA. Calcification by valve interstitial cells is regulated by the stiffness of the extracellular matrix. Arterioscler Thromb Vasc Biol, 2009;29:936-942. Supplemental material.| PubMed
Simmons CA. Aortic valve mechanics: an emerging role for the endothelium. J Am Coll Cardiol, 2009;53:1456-1458. | PubMed
Chen JH, Yip CY, Sone ED, Simmons CA. Identification and characterization of aortic valve mesenchymal progenitor cells with robust osteogenic calcification potential. Am J Pathology, 2009;174:1109-1119. | Pubmed
Fiddes L, Chan HK, Wyss K, Simmons CA, Kumacheva E, Wheeler AR. Augmenting microgel flow via receptor-ligand binding in the constrained geometries of microchannels. Lab Chip, 2009;9:286-290.| PubMed
Young EWK, Simmons CA. “Student lab”-on-a-chip: Integrating low-cost microfluidics into undergraduate teaching labs to study multiphase flow phenomena in small vessels. Chem Eng Educ, 2009;43:232-240.| PubMed
Moraes C, Sun Y, Simmons CA. Solving the shrinkage-induced PDMS alignment registration issue in multilayer soft lithography. J Micromech Microeng, 2009;19:065015.| PubMed
Cheung WY*, Young EWK*, Simmons CA. Techniques for isolating and purifying porcine aortic valve endothelial cells. J Heart Valve Dis, 2008;17:674-681.| PubMed
Spiteri C, Young EWK, Simmons CA, Pilliar RM, Kandel RA. Substrate architecture and fluid-induced shear stress during chondrocyte seeding: Role of α5β1 integrin. Biomaterials, 2008; 29:2477-2489.| PubMed
Pho M, Lee W, Watt DR, Laschinger C, Simmons CA, McCulloch CA. Cofilin is a marker of myofibroblast differentiation in cells from porcine aortic cardiac valves. Am J Physiol Heart Circ, 2008;294:H1767-1778.| PubMed
Butcher JT, Simmons CA, Warnock JN. Mechanobiology of the aortic heart valve. J Heart Valve Dis, 2008;17:62-73.| PubMed
Li W, Young EWK, Seo M, Nie Z, Garstecki P, Simmons CA, Kumacheva, E. Simultaneous microfluidic generation of droplets with different dimensions. Soft Matter, 2008;4:258-262.| PubMed
Tong J, Simmons CA, Sun Y. Precision patterning of PDMS membranes and applications. Journal Micromech Microeng,2008;18:037004 (5 pp).| PubMed
Young EWK, Wheeler AR, Simmons CA. Matrix-dependent adhesion of vascular and valvular endothelial cells in microfluidic channels. Lab Chip, 2007;7:1759-1766.| PubMed
Chong SA, Lee W, Arora PD, Laschinger C, Young EWK, Simmons CA, Manolson M, Sodek J, McCulloch CA. Methylglyoxal inhibits the binding step of collagen phagocytosis. J Biol Chem, 2007; 282:8510-8520.| PubMed
Moraes C, Simmons CA, Sun Y. Cell mechanics meets MEMS. CSME Bulletin, Fall 2006.| PubMed
Simmons CA, Grant GR, Manduchi E, Davies PF. Spatial heterogeneity of endothelial phenotypes correlates with side-dependent vulnerability to calcification in normal porcine aortic valves. Circ Res, 2005;96:792-799. Supplemental data /Supplemental material| PubMed
Huang YC, Simmons CA, Kaigler D, Rice KG, Mooney DJ. Bone regeneration in a rat cranial defect with delivery of PEI-condensed plasmid DNA encoding for bone morphogenetic protein-4 (BMP-4). Gene Ther, 2005;12:418-426.| PubMed
Murphy WL, Hsiong S, Richardson TP, Simmons CA, Mooney DJ. Effects of a bone-like mineral film on phenotype of adult human mesenchymal stem cells in vitro. Biomaterials, 2005; 26:303-310.| PubMed
Simmons CA, Nikolovski J, Thornton AJ, Matlis S, Mooney DJ. Mechanical stimulation and mitogen-activated protein kinase signaling independently regulate osteogenic differentiation and mineralization by calcifying vascular cells. J Biomech,2004;37:1531-1541.| PubMed
Simmons CA, Zilberberg J, Davies PF. A rapid, reliable method to isolate high quality endothelial RNA from small spatially-defined locations. Ann Biomed Eng, 2004;32:1453-1459.| PubMed
Simmons CA, Alsberg E, Hsiong S, Kim WJ, Mooney DJ. Dual growth factor delivery and controlled scaffold degradation enhance in vivo bone formation by transplanted bone marrow stromal cells. Bone, 2004;35:562-569.| PubMed
Davies PF, Passerini AG, Simmons CA. Aortic valve: turning over a new leaf(let) in endothelial phenotypic heterogeneity.Arterioscler Thromb Vasc Biol, 2004;24:1331-1333.| PubMed
Murphy WL*, Simmons CA*, Kaigler D, Mooney DJ. Bone regeneration via a mineral substrate and induced angiogenesis. J Dent Res, 2004;83:204-210.| PubMed
Simmons CA, Matlis S, Thornton AJ, Chen S, Wang CY, Mooney DJ. Cyclic strain enhances matrix mineralization by adult human mesenchymal stem cells via the extracellular signal-regulated kinase (ERK1/2) signaling pathway. J Biomech,2003;36:1087-1096.| PubMed
Simmons CA, Meguid SA, Pilliar RM. Mechanical regulation of localized and appositional bone formation around bone-interfacing implants. J Biomed Mater Res, 2001;55:63-71.| PubMed
Simmons CA, Meguid SA, Pilliar RM. Differences in osseointegration rate due to implant surface geometry can be explained by local tissue strains. J Orthop Res, 2001;19:187-194.| PubMed
Simmons CA, Valiquette N, Pilliar RM. Osseointegration of sintered porous-surfaced and plasma spray-coated implants: An animal model study of early postimplantation healing response and mechanical stability. J Biomed Mater Res, 1999;47:127-138.| PubMed
Simmons CA, Hipp JA. Method-based differences in the automated analysis of the three-dimensional morphology of trabecular bone. J Bone Miner Res, 1997;12:942-947.| PubMed
Hipp JA, Jansujwicz A, Simmons CA, Snyder BD. Trabecular bone morphology from micro-magnetic resonance imaging. J Bone Miner Res, 1996;11:286-297.| PubMed
Elke RP, Cheal EJ, Simmons C, Poss R. Three-dimensional anatomy of the cancellous structures within the proximal femur from computed tomography data. J Orthop Res, 1995;13:513-523.| PubMed