Liu Haijiao, MacQueen Luke A., Usprech Jenna F., Maleki Hoda, Sider Krista L., Doyle Matthew G., Sun Yu, Simmons Craig A. Microdevice arrays with strain sensors for 3D mechanical stimulation and monitoring of engineered tissues. Biomaterials. 2018;172:30-40 |ScienceDirect
Tag Archives: Biomechanics
Zhong, Aileen, Mirzaei, Zahra, Simmons, Craig A. The Roles of Matrix Stiffness and ß-Catenin Signaling in Endothelial-to- Mesenchymal Transition of Aortic Valve Endothelial Cells. Cardiovascular Engineering and Technology. 2018;9:158-167|Springer
Blaser MC, Wei K, Adams RLE, Zhou YQ, Caruso LL, Mirzaei Z, Lam AY, Tam RKK, Zhang H, Heximer SP, Henkelman RM, Simmons CA. Deficiency of Natriuretic Peptide Receptor 2 Promotes Bicuspid Aortic Valves, Aortic Valve Disease, Left Ventricular Dysfunction, and Ascending Aortic Dilatations in Mice. Circulation Research. 2018; 2(122): 405-416 | PubMed
Ebady R, Niddam AF, Boczula AE, Kim YR, Gupta N, Tang TT, Odisho T, Zhi H, Simmons CA, Skare JT, Moriarty TJ. Biomechanics of Borrelia burgdorferi vascular interactions. Cell Rep. 2016;16(10):2593-604. | PubMed
Parvin Nejad S, Blaser MC, Santerre JPS, Caldarone CA, Simmons CA. Biomechanical conditioning of tissue engineered heart valves: Too much of a good thing? Advanced Drug Delivery Reviews, 2016;96:161-75. | PubMed
Ireland R, Simmons CA. Pluripotent stem cell mechanobiology. Stem Cells (invited review), 2015;33:3187-96. | PubMed
Niu CJ, Fisher C, Scheffler K, Wana R, Maleki H, Liu H, Sun Y, Simmons CA, Birngruber R, Lilge L. Polyacrylamide gel substrates that simulate the mechanical stiffness of normal and malignant neuronal tissues increase protoporphyin IX synthesis in glioma cells. Journal of Biomedical Optics, 2015;20:98002. | PubMed
Plaza GR, Uyeda TQP, Mirzaei Z, Simmons CA. Study of the influence of actin-binding proteins using linear analyses of cell deformability. Soft Matter, 2015;11:5435-46. | PubMed
Battiston KG, Labow RS, Simmons CA, Santerre JP. Immunomodulatory polymeric scaffold enhances extracellular matrix production in cell co-cultures under dynamic mechanical stimulation. Acta Biomaterialia, 2015;24:74-86. | PubMed
Lau K, Tao H, Liu H, Wen J, Sturgeon K, Sorfazlian N, Lazic S, Burrows JTA, Wong M, Li D, Deimling S, Ciruna B, Scott I, Simmons CA, Henkelman RM, Williams T, Hadjantonakis AK, Fernandez-Gonzalez R, Sun Y, Hopyan S. Anisotropic stress orients remodelling of mammalian limb bud ectoderm. Nat Cell Biol, 2015;17:569–579. | PubMed
Mohammadi H, Arora PD, Simmons CA, Janmey PA, McCulloch CA. Inelastic behaviour of collagen networks in cell-matrix interactions and mechanosensation. J R Soc Interface, 2015;12:20141074 | PubMed
Sider KL, Zhu C, Kwong AV, Mirzaei Z, De Lange CFM, Simmons CA. Evaluation of a porcine model of early aortic valve sclerosis. Cardiovasc Pathol, 2014;23:289-97.| PubMed
Liu H, Wen J, Xiao Y, Liu J, Hopyan S, Radisic M, Simmons CA#, Sun Y#. In situ mechanical characterization of the cell nucleus by atomic force microscopy. ACS Nano, 2014;8:3821-8.| PubMed
Liu H, Tan Q, Geddie WR, Jewett MAS, Phillips N, Ke D, Simmons CA, Sun Y. Biophysical characterization of bladder cancer cells with different metastatic potential. Cell Biochem Biophys, 2014; 68:241-97.| PubMed
Zhao R, Simmons CA. A simple method to estimate the exponential material parameters of heart valve tissue based on analogy between uniaxial tension and micropipette aspiration. Biomech Model Mechanobiol, 2013;12:1283-90.| PubMed
Liu H, Sun Y, Simmons CA. Determination of local and global elastic moduli of valve interstitial cells cultured on soft substrates. J Biomech, 2013;46:1967-71.| PubMed
Gould ST, Srigunapalan S, Simmons CA, Anseth KS. Hemodynamic and cellular response feedback in calcific aortic valve disease. Circ Res, 2013;113:186-97.| PubMed
Macqueen L, Sun Y, Simmons CA. Mesenchymal stem cell mechanobiology and emerging experimental platforms. J R Soc Interface, 2013;10:20130179.| PubMed
Moraes C*, Likhitpanichkul M*, Lam CJ, Beca BM, Sun Y, Simmons CA. Microdevice array-based identification of distinct mechanobiological response profiles in layer-specific valve interstitial cells. Integr Biol, 2013;5:673-80.| PubMed
Al-Haque S, Miklas JW, Feric N, Chiu LL, Chen WL, Simmons CA, Radisic M. Hydrogel substrate stiffness and topography interact to induce contact guidance in cardiac fibroblasts. Macromol Biosci, 2012;12:1342-53.| PubMed
Wyss K, Yip CYY, Mirzaei Z, Jin X, Chen JH, Simmons CA. The elastic properties of valve interstitial cells undergoing pathological differentiation. J Biomech, 2012;45:882-887. Supplemental material.| PubMed
Zhao R, Simmons CA. An improved texture correlation algorithm to measure substrate-cytoskeletal network strain transfer under large compressive strain. J Biomech, 2012;45:76-82.| PubMed
Rajamannan NM, Evans FJ, Aikawa E, Grande-Allen KJ, Demer LL, Heistad DD, Simmons CA, Masters KS, Mathieu P, O’Brien KD, Schoen FJ, Towler DA, Yoganathan AP, Otto CM. Calcific aortic valve disease: not simply a degenerative process: A review and agenda for research from the National Heart and Lung and Blood Institute Aortic Stenosis Working Group Executive Summary: Calcific aortic valve disease – 2011 update. Circulation,2011;124:1783-91.| PubMed
Young EWK, Wheeler AR, Simmons CA. Avoiding bubble injection by droplet merging. Chips & Tips (online supplement to Lab on a Chip), Oct. 23, 2006. | PubMed
Sharifpoor S, Simmons CA, Labow RS, Paul Santerre J. Functional characterization of human coronary artery smooth muscle cells under cyclic mechanical strain in a degradable polyurethane scaffold. Biomaterials,2011;32:4816-4829.| PubMed
Chen JH, Simmons CA. Cell–matrix interactions in the pathobiology of calcific aortic valve disease. Circ Res,2011;108:1510-1524.| PubMed
Yip CYY, Simmons CA. The aortic valve microenvironment and its role in calcific aortic valve disease.Cardiovascular Pathology,2011;20:177-182.| PubMed
Chen WLK, Simmons CA. Lessons from (patho)physiological tissue stiffness and their implications for drug screening, drug delivery and regenerative medicine. Advanced Drug Delivery Reviews, 2011;63:269-276.| PubMed
Cheung WY, Liu C, Tonelli-Zasarsky RML, Simmons CA#, You L#. Osteocyte apoptosis is mechanically regulated and induces angiogenesis in vitro. J Orthop Res, 2011;29:523-530.| PubMed
Zhao R*, Sider KL*, Simmons CA. Measurement of layer-specific mechanical properties in multilayered biomaterials by micropipette aspiration. Acta Biomaterialia, 2011;7:1220-1227.| PubMed
Sharifpoor S, Simmons CA, Labow RS, Santerre JP. A study of vascular smooth muscle cell function under cyclic mechanical loading in a degradable polyurethane scaffold with optimized porosity. Acta Biomaterialia, 2010;6:4218-4228. | PubMed
Eilaghi A, Flanagan JG, Tertinegg I, Simmons CA, Brodland GW, Ethier CR. Biaxial mechanical testing of human sclera. J Biomech, 2010;43:1696-1701. | PubMed
Bhana B, Iyer RK, Chen WL, Zhao R, Sider KL, Likhitpanichkul M, Simmons CA, Radisic M. Influence of substrate stiffness on the phenotype of heart cells. Biotechnol Bioeng, 2010;105:1148-1160. Journal cover| PubMed
Eilaghi A, Flanagan JG, Simmons CA, Ethier CR. Effects of scleral stiffness properties on optic nerve head biomechanics. Ann Biomed Eng, 2010;38:1586-1592. | PubMed
Chen WLK, Likhitpanichkul M, Ho A, Simmons CA. Integration of statistical modeling and high-content microscopy to systematically investigate cell-substrate interactions. Biomaterials, 2010;31:2489-2497.| PubMed
Young EWK, Watson ML, Srigunapalan S, Wheeler AR, Simmons CA. Technique for real-time measurements of endothelial permeability in a microfluidic membrane chip using laser-induced fluorescence detection. Anal Chem,2010;82:808-816.| PubMed
Chen JH, Liu C, You L, Simmons CA. Boning up on Wolff’s Law: Mechanical regulation of the cells that make and maintain bone. J Biomech, 2010;43:108-118.| PubMed
Zhao R, Wyss K, Simmons CA. Comparison of analytical and inverse finite element approaches to estimate cell viscoelastic properties by micropipette aspiration. J Biomech, 2009;42:2768-2773. Supplemental material| PubMed
Yip CY, Chen JH, Zhao R, Simmons CA. Calcification by valve interstitial cells is regulated by the stiffness of the extracellular matrix. Arterioscler Thromb Vasc Biol, 2009;29:936-942. Supplemental material.| PubMed
Simmons CA. Aortic valve mechanics: an emerging role for the endothelium. J Am Coll Cardiol, 2009;53:1456-1458. | PubMed
Spiteri C, Young EWK, Simmons CA, Pilliar RM, Kandel RA. Substrate architecture and fluid-induced shear stress during chondrocyte seeding: Role of α5β1 integrin. Biomaterials, 2008; 29:2477-2489.| PubMed
Butcher JT, Simmons CA, Warnock JN. Mechanobiology of the aortic heart valve. J Heart Valve Dis, 2008;17:62-73.| PubMed
Moraes C, Simmons CA, Sun Y. Cell mechanics meets MEMS. CSME Bulletin, Fall 2006.| PubMed
Simmons CA, Nikolovski J, Thornton AJ, Matlis S, Mooney DJ. Mechanical stimulation and mitogen-activated protein kinase signaling independently regulate osteogenic differentiation and mineralization by calcifying vascular cells. J Biomech,2004;37:1531-1541.| PubMed
Simmons CA, Matlis S, Thornton AJ, Chen S, Wang CY, Mooney DJ. Cyclic strain enhances matrix mineralization by adult human mesenchymal stem cells via the extracellular signal-regulated kinase (ERK1/2) signaling pathway. J Biomech,2003;36:1087-1096.| PubMed
Simmons CA, Meguid SA, Pilliar RM. Mechanical regulation of localized and appositional bone formation around bone-interfacing implants. J Biomed Mater Res, 2001;55:63-71.| PubMed
Simmons CA, Meguid SA, Pilliar RM. Differences in osseointegration rate due to implant surface geometry can be explained by local tissue strains. J Orthop Res, 2001;19:187-194.| PubMed
Simmons CA, Valiquette N, Pilliar RM. Osseointegration of sintered porous-surfaced and plasma spray-coated implants: An animal model study of early postimplantation healing response and mechanical stability. J Biomed Mater Res, 1999;47:127-138.| PubMed
Simmons CA, Hipp JA. Method-based differences in the automated analysis of the three-dimensional morphology of trabecular bone. J Bone Miner Res, 1997;12:942-947.| PubMed
Hipp JA, Jansujwicz A, Simmons CA, Snyder BD. Trabecular bone morphology from micro-magnetic resonance imaging. J Bone Miner Res, 1996;11:286-297.| PubMed
Elke RP, Cheal EJ, Simmons C, Poss R. Three-dimensional anatomy of the cancellous structures within the proximal femur from computed tomography data. J Orthop Res, 1995;13:513-523.| PubMed