Blaser MC, Wei K, Adams RLE, Zhou YQ, Caruso LL, Mirzaei Z, Lam AY, Tam RKK, Zhang H, Heximer SP, Henkelman RM, Simmons CA. Deficiency of Natriuretic Peptide Receptor 2 Promotes Bicuspid Aortic Valves, Aortic Valve Disease, Left Ventricular Dysfunction, and Ascending Aortic Dilatations in Mice. Circulation Research. 2018; 2(122): 405-416 | PubMed
Tag Archives: HeartValve
Usprech J, Chen WLK, Simmons CA. Heart valve regeneration: The need for systems approaches. WIRE Systems Biology and Medicine, 2016; 8:169-82. | PubMed
Parvin Nejad S, Blaser MC, Santerre JPS, Caldarone CA, Simmons CA. Biomechanical conditioning of tissue engineered heart valves: Too much of a good thing? Advanced Drug Delivery Reviews, 2016;96:161-75. | PubMed
Kheradvar A, Groves EM, Falahatpisheh A, Mofrad MK, Alavi SH, Tranquillo R, Dasi LP, Simmons CA, Grande-Allen KJ, Goergen CJ, Baaijens F, Little SH, Canic S, Griffith B. Emerging trends in heart valve engineering: Part IV. Computational modeling and experimental studies. Ann Biomed Eng, 2015;43:2314-33. | PubMed
Kheradvar A, Groves EM, Dasi LP, Alavi SH, Tranquillo RT, Grande-Allen KJ, Simmons CA, Griffith BE, Falahatpisheh A, Goergen CJ, Mofrad MRK, Baaijens FPT, Little SH, Canic S. Emerging trends in heart valve engineering: Part I. Solutions for the future. Ann Biomed Eng, 2015;43:833-43. | PubMed
Kheradvar A, Groves EM, Goergen CJ, Alavi SH, Tranquillo RT, Simmons CA, Dasi LP, Grande-Allen KJ, Mofrad MRK, Falahatpisheh A, Griffith BE, Baaijens FPT, Little SH, Canic S. Emerging trends in heart valve engineering: Part II. Novel and standard technologies for aortic valve replacement. Ann Biomed Eng, 2015;43:844-57. | PubMed
Kheradvar A, Groves EM, Simmons CA, Griffith BE, Hamed Alavi S, Tranquillo RT, Dasi LP, Falahatpisheh A, Grande-Allen KJ, Goergen CJ, Mofrad MRK, Baaijens FPT, Canic S, Little SH. Emerging trends in heart valve engineering: Part III. Novel technologies for mitral valve repair and replacement. Ann Biomed Eng, 2015;43:858-70. | PubMed
Battiston KG, Ouyang B, Labow RS, Simmons CA, Santerre JP. Using monocytes/macrophages and their cytokine activity to promote vascular smooth muscle cell growth on a degradable polyurethane scaffold. Acta Biomaterialia, 2014;10:1146-55. | PubMed
Sider KL, Zhu C, Kwong AV, Mirzaei Z, De Lange CFM, Simmons CA. Evaluation of a porcine model of early aortic valve sclerosis. Cardiovasc Pathol, 2014;23:289-97.| PubMed
Zhao R, Simmons CA. A simple method to estimate the exponential material parameters of heart valve tissue based on analogy between uniaxial tension and micropipette aspiration. Biomech Model Mechanobiol, 2013;12:1283-90.| PubMed
Liu H, Sun Y, Simmons CA. Determination of local and global elastic moduli of valve interstitial cells cultured on soft substrates. J Biomech, 2013;46:1967-71.| PubMed
Gould ST, Srigunapalan S, Simmons CA, Anseth KS. Hemodynamic and cellular response feedback in calcific aortic valve disease. Circ Res, 2013;113:186-97.| PubMed
Wyss K, Yip CYY, Mirzaei Z, Jin X, Chen JH, Simmons CA. The elastic properties of valve interstitial cells undergoing pathological differentiation. J Biomech, 2012;45:882-887. Supplemental material.| PubMed
Rajamannan NM, Evans FJ, Aikawa E, Grande-Allen KJ, Demer LL, Heistad DD, Simmons CA, Masters KS, Mathieu P, O’Brien KD, Schoen FJ, Towler DA, Yoganathan AP, Otto CM. Calcific aortic valve disease: not simply a degenerative process: A review and agenda for research from the National Heart and Lung and Blood Institute Aortic Stenosis Working Group Executive Summary: Calcific aortic valve disease – 2011 update. Circulation,2011;124:1783-91.| PubMed
Chen JH, Simmons CA. Cell–matrix interactions in the pathobiology of calcific aortic valve disease. Circ Res,2011;108:1510-1524.| PubMed
Yip CYY, Simmons CA. The aortic valve microenvironment and its role in calcific aortic valve disease.Cardiovascular Pathology,2011;20:177-182.| PubMed
Sider KL*, Blaser MC*, Simmons CA. Animal models of calcific aortic valve disease. Int J Inflam, 2011; 364310.| PubMed
Simmons CA. Aortic valve mechanics: an emerging role for the endothelium. J Am Coll Cardiol, 2009;53:1456-1458. | PubMed
Chen JH, Yip CY, Sone ED, Simmons CA. Identification and characterization of aortic valve mesenchymal progenitor cells with robust osteogenic calcification potential. Am J Pathology, 2009;174:1109-1119. | Pubmed
Cheung WY*, Young EWK*, Simmons CA. Techniques for isolating and purifying porcine aortic valve endothelial cells. J Heart Valve Dis, 2008;17:674-681.| PubMed
Butcher JT, Simmons CA, Warnock JN. Mechanobiology of the aortic heart valve. J Heart Valve Dis, 2008;17:62-73.| PubMed
Simmons CA, Grant GR, Manduchi E, Davies PF. Spatial heterogeneity of endothelial phenotypes correlates with side-dependent vulnerability to calcification in normal porcine aortic valves. Circ Res, 2005;96:792-799. Supplemental data /Supplemental material| PubMed
Davies PF, Passerini AG, Simmons CA. Aortic valve: turning over a new leaf(let) in endothelial phenotypic heterogeneity.Arterioscler Thromb Vasc Biol, 2004;24:1331-1333.| PubMed