Bahram Mirani

Mechanical or bioprosthetic heart valve replacements, as the only treatment options for valvular heart disease, do not result in ideal outcomes due to the risk of blood coagulation or regradation, and particularly, are not suitable for young patients as they do not grow, remodel, and repair. Alternatively, tissue engineering of heart valve holds the promise of providing heart valves with regenerative capability. My research, primarily, focuses on the development of a tissue-engineered heart valve with mechanical, structural, and material properties similar to those of native heart valve tissue.