Lauren Durland

B.Sc. Candidate
Department of Molecular Genetics
Joined in 2020.

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Research Description:

Pluripotent stem cell (PSC)-derived cardiomyocytes are largely representative of embryonic or fetal stages of development, which greatly hinders their utility in pre-clinical applications such as disease modelling and cardiotoxicity assessment. Current maturation approaches often include mixtures of biochemical factors with known roles in maturation in vivo, or 3D tissue constructs that aim to recapitulate key features of the in vivo myocardial environment. My thesis project is focusing on comparing the effectiveness of existing maturation approaches at the transcriptome level. Additionally, I am investigating whether combining biochemical and 3D approaches promotes enhanced maturation of functional properties, including calcium handling and contractile force production.

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