Institute of Biomaterials & Biomedical Engineering
Joined in 2013.
My research focuses on engineering valve tissue for the repair or replacement of the stenotic pulmonary valve in pediatric patients with Tetralogy of Fallot. Our goal is to produce an autologous valve-like tissue that can grow, repair, and remodel by culturing and conditioning mesenchymal stromal cells from the umbilical cord (human umbilical cord perivascular cells) on biodegradable electrospun polyurethane scaffolds.
Mirani Bahram, Parvin Nejad Shouka, Simmons Craig A. Recent progress toward clinical translation of tissue engineered heart valves. Canadian Journal of Cardiology. 2021 | Elsevier
Parvin Nejad S, Blaser MC, Santerre JPS, Caldarone CA, Simmons CA. Biomechanical conditioning of tissue engineered heart valves: Too much of a good thing? Advanced Drug Delivery Reviews, 2016;96:161-75. | PubMed