Institute of Biomaterials & Biomedical Engineering
Joined in 2013.
Aortic sclerosis, the early stage of calcific aortic valve disease (CAVD), occurs at a much higher rate and earlier in life in patients with bicuspid aortic valves (BAVs) for unknown reasons. A bicuspid aortic valves is a congenital birth defect in which the aortic valve has only two leaflets, not the normal three of a tricuspid valve, and therefore experiences a higher degree of biomechanical stress due to altered blood flow, or hemodynamics. C-type natriuretic peptide (CNP), a signaling protein that influences activation of valve interstitial cells (VICs) in the valve leaflets, has been studied for its protective effect and maintenance of valve homostasis. My research aims to characterize signaling pathways and valve disease in human tissue and mice with BAVs to provide insight into CAVD.Recent News
- Rachel wins Lorne Phenix award
- Rachel, Chien, and Cam receive summer research awards!
- Congratulations to Ali, Billy, Bogdan, Catherine, Ian, Rachel, and Suthan, who all received summer research fellowships!
Blaser MC, Wei K, Adams RLE, Zhou YQ, Caruso LL, Mirzaei Z, Lam AY, Tam RKK, Zhang H, Heximer SP, Henkelman RM, Simmons CA. Deficiency of Natriuretic Peptide Receptor 2 Promotes Bicuspid Aortic Valves, Aortic Valve Disease, Left Ventricular Dysfunction, and Ascending Aortic Dilatations in Mice. Circulation Research. 2018; 2(122): 405-416 | PubMed