Neal Callaghan

Ph.D. Candidate
Institute of Biomaterials & Biomedical Engineering
Joined in 2016. 

Contact Information
E-mail: neal.callaghan@mail.utoronto.ca
Office Tel: (416) 978 7365

Research overview

Cardiomyocytes, or the muscle cells of the heart, power contractions continuously through our lives. In the lab, we can use simple cultures or more involved organ-on-a-chip devices to probe normal working physiology, the progression and pathophysiology of diseases, or mechanisms of pharmaceutical cardiotoxicity (the chief reason for drug recalls or clinical trial failures!). However, cardiomyocytes are difficult to culture so that they mirror real heart function, in terms of mechanics, cell morphology, electrophysiology, and metabolism. I am working to develop novel culture strategies and functional measurements of both primary and stem cell-derived cardiomyocytes to make more ensure safer and more accurate drug testing, as well as new tools to probe myocardial physiology.

Recent News Publications
  • Callaghan Neal I., Lee Shin-Haw, Hadipour-Lakmehsari Sina, Lee Xavier A., Siraj M. Ahsan, Driouchi Amine, Yip Christopher M., Husain Mansoor,Simmons Craig A., Gramolini Anthony O., Functional culture and in vitro genetic and small-molecule manipulation of adult mouse cardiomyocytes. Communications Biology. 2020 | Nature Publishing Group 

  • Hadipour-Lakmehsari Sina, Driouchi Amine, Lee Shin-Haw, Kuzmanov Uros, Callaghan Neal I., Heximer Scott P., Simmons Craig A., Yip Christopher M., Gramolini Anthony O., Nanoscale reorganization of sarcoplasmic reticulum in pressure-overload cardiac hypertrophy visualized by dSTORM. Scientific Reports. 2019 | Nature Publishing Group 

  • Callaghan Neal, Hadipour-Lakmehsari Sina, Lee Shin-Haw, Gramolini Anthony O., Simmons Craig A., Modeling cardiac complexity: Advancements in myocardial models and analytical techniques for physiological investigation and therapeutic development in vitro. APL Bioengineering. 2019 | AIP