Institute of Biomaterials and Biomedical Engineering
Joined in 2011.
Hypertension is a major risk factor for calcific aortic valve disease. Increased blood pressure has been linked to elevated mechanical strain on the aortic valve leaflets. My research aims to identify and characterize mechanical strain-regulated signaling pathways in valve interstitial cell osteogenic differentiation.Recent News
Fitzsimmons Ross E.B., Ireland Ronald G., Zhong Aileen., Soos Agnes, Simmons Craig A., Assessment of fibrin-collagen co-gels for generating microvessels ex vivo using endothelial cell-lined microfluidics and multipotent stromal cell (MSC)-induced capillary morphogenesis. Biomedical Materials. 2020 | IOP Science.
Zhong, Aileen, Mirzaei, Zahra, Simmons, Craig A. The Roles of Matrix Stiffness and ß-Catenin Signaling in Endothelial-to- Mesenchymal Transition of Aortic Valve Endothelial Cells. Cardiovascular Engineering and Technology. 2018;9:158-167|Springer
Zhong A, Simmons CA. Heart valve mechanobiology in development and disease. In: Chien S, Engler AJ, Wang Y (eds.) Molecular and Cellular Mechanobiology. American Physiological Society, 2016. | Book Chapter