Publications

To request reprints of any of these articles, please contact Craig Simmons.

85. Sider KL, Zhu C, Kwong AV, Mirzaei Z, De Lange CFM, Simmons CA. Evaluation of a porcine model of early aortic valve sclerosis. Cardiovasc Pathol, in press.
84. Liu H, Wen J, Xiao Y, Liu J, Hopyan S, Radisic M, Simmons CA#, Sun Y#. In situ mechanical characterization of the cell nucleus by atomic force microscopy. ACS Nano, 2014;8:3821-8.
83. Battiston KG, Ouyang B, Labow RS, Simmons CA, Santerre JP. Using monocytes/macrophages and their cytokine activity to promote vascular smooth muscle cell growth on a degradable polyurethane scaffold. Acta Biomaterialia, 2014;10:1146-55.
82. Xiao Y, Zhang B, Liu H, Miklas JW, Gagliardi M, Pahnke A, Thavandiran N, Sun Y, Simmons CA, Keller G, Radisic M. Microfabricated perfusable cardiac biowire: a platform that mimics native cardiac bundle. Lab Chip, 2014;14:869-82.
81. Tan Q*, Liu H*, Geddie WR, Jewett MAS, Simmons CA, Sun Y. Biophysical characterization of bladder cancer cells with different metastatic potential. Cell Biochemistry and Biophysics, 2014;68:241-6.
80. Thavandiran N, Dubois N, Mikryukov A, Masse S, Beca B, Simmons CA, Deshpande V, McGarry P, Chen CS, Nanthakumar K, Keller G, Radisic M, Zandstra PW. Design and formulation of functional pluripotent stem cell-derived cardiac microtissues. Proc Natl Acad Sci U S A, 2013;110:E4698-707.
79. Heckler AF, Mirzaei Z, Pereira I, Simmons CA, Gong S-G. Development of a three-dimensional in vitro model system to study orthodontic tooth movement. Arch Oral Biol, 2013;58:1498-1510.
78. Gould ST, Srigunapalan S, Simmons CA, Anseth KS. Hemodynamic and cellular response feedback in calcific aortic valve disease. Circ Res, 2013;113:186-97.
77. Liu H, Tan Q, Geddie WR, Jewett MAS, Phillips N, Ke D, Simmons CA, Sun Y. Biophysical characterization of bladder cancer cells with different metastatic potential. Cell Biochem Biophys, in press. DOI:10.1007/s12013-013-9702-9.
76. Liu H, Sun Y, Simmons CA. Determination of local and global elastic moduli of valve interstitial cells cultured on soft substrates. J Biomech, 2013;46:1967-71. DOI:10.1016/j.jbiomech.2013.05.001.
75. Macqueen L, Sun Y, Simmons CA. Mesenchymal stem cell mechanobiology and emerging experimental platforms. J R Soc Interface, 2013;10:20130179. DOI:10.1098/​rsif.2013.0179.
74. Chen MB, Srigunapalan S, Wheeler AR, Simmons CA. A 3D microfluidic platform incorporating methacrylated gelatin hydrogels to study physiological cardiovascular cell–cell interactions. Lab Chip, 2013;13:2591-8. DOI:10.1039/C3LC00051F.
73. Moraes C*, Likhitpanichkul M*, Lam CJ, Beca BM, Sun Y, Simmons CA. Microdevice array-based identification of distinct mechanobiological response profiles in layer-specific valve interstitial cells. Integr Biol, 2013;5:673-80. DOI:10.1039/C3IB20254B.
72. Zhao R, Simmons CA. A simple method to estimate the exponential material parameters of heart valve tissue based on analogy between uniaxial tension and micropipette aspiration. Biomech Model Mechanobiol, 2013;12:1283-90. DOI:10.1007/s10237-013-0470-7
71. Srigunapalan S*, Eydelnant IA*, Simmons CA, Wheeler AR. A digital microfluidic platform for primary cell culture and analysis. Lab Chip, 2012;12:369-75. DOI:10.1039/c1lc20844f.
70. Liu J*, Moraes C*, Lu Z, Simmons CA, Sun Y. Single cell deposition. Methods Cell Biol, 2012;112:403-420.
69. Al-Haque S, Miklas JW, Feric N, Chiu LL, Chen WL, Simmons CA, Radisic M. Hydrogel substrate stiffness and topography interact to induce contact guidance in cardiac fibroblasts. Macromol Biosci, 2012;12:1342-53.
68. MacQueen L, Chebotarev O, Simmons CA#, Sun Y#. Miniaturized platform with on-chip strain sensors for compression testing of arrayed materials. Lab Chip, 2012;12:4178-84. DOI: 10.1039/c2lc40670e.
67. Wyss K, Yip CYY, Mirzaei Z, Jin X, Chen JH, Simmons CA. The elastic properties of valve interstitial cells undergoing pathological differentiation. J Biomech, 2012;45:882-887. Supplemental material
66. Zhao R, Simmons CA. An improved texture correlation algorithm to measure substrate-cytoskeletal network strain transfer under large compressive strain. J Biomech, 2012;45:76-82.
65. Rajamannan NM, Evans FJ, Aikawa E, Grande-Allen KJ, Demer LL, Heistad DD, Simmons CA, Masters KS, Mathieu P, O'Brien KD, Schoen FJ, Towler DA, Yoganathan AP, Otto CM. Calcific aortic valve disease: not simply a degenerative process: A review and agenda for research from the National Heart and Lung and Blood Institute Aortic Stenosis Working Group Executive Summary: Calcific aortic valve disease - 2011 update. Circulation, 2011;124:1783-91.
64. Cheung WY, Simmons CA#, You L#. Osteocyte apoptosis regulates osteoclast precursor adhesion via osteocytic IL-6 secretion and endothelial ICAM-1 expression. Bone, 2012;50:104-110.
63. Moraes C, Sun Y#, Simmons CA#. (Micro) managing the mechanical microenvironment. Integr Biol, 2011;3:959-971.
62. Sider KL*, Blaser MC*, Simmons CA. Animal models of calcific aortic valve disease. Int J Inflam, 2011; 364310. doi:10.4061/2011/364310
61. Yip CY, Blaser MC, Mirzaei Z, Zhong X, Simmons CA. Inhibition of pathological differentiation of valve interstitial cells by C-type natriuretic peptide. Arterioscler Thromb Vasc Biol, 2011;31:1881-1889. Supplemental material
60. Chen JH, Simmons CA. Cell–matrix interactions in the pathobiology of calcific aortic valve disease. Circ Res, 2011;108:1510-1524.
59. Sharifpoor S, Simmons CA, Labow RS, Paul Santerre J. Functional characterization of human coronary artery smooth muscle cells under cyclic mechanical strain in a degradable polyurethane scaffold. Biomaterials, 2011;32:4816-4829.
58. Moraes C, Zhao R, Likhitpanichkul M, Simmons CA#, Sun Y#. Semi-confined compression of microfabricated polymerized biomaterial constructs. J Micromech Microeng, 2011;21:doi:054014
57. Yip CYY, Simmons CA. The aortic valve microenvironment and its role in calcific aortic valve disease. Cardiovascular Pathology, 2011;20:177-182.
56. Chen WLK, Simmons CA. Lessons from (patho)physiological tissue stiffness and their implications for drug screening, drug delivery and regenerative medicine. Advanced Drug Delivery Reviews, 2011;63:269-276.
55. Srigunapalan S, Lam C, Wheeler AR, Simmons CA. A microfluidic membrane device to mimic critical components of the vascular microenvironment. Biomicrofluidics, 2011;5:13409.
54. Chen JH, Chen WLK, Sider KL, Yip CYY and Simmons CA. β-catenin mediates mechanically regulated, transforming growth factor-β1 induced myofibroblast differentiation of aortic valve interstitial cells. Arterioscler Thromb Vasc Biol, 2011;31:590-597. Supplemental material / Commentary
53. Zhao R*, Sider KL*, Simmons CA. Measurement of layer-specific mechanical properties in multilayered biomaterials by micropipette aspiration. Acta Biomaterialia, 2011;7:1220-1227.
52. Lu Z*, Moraes C*, Ye G, Simmons CA, Sun Y. Single cell deposition and patterning with a robotic system. PLoS One, 2010;5:e13542.
51. Cheung WY, Liu C, Tonelli-Zasarsky RML, Simmons CA#, You L#. Osteocyte apoptosis is mechanically regulated and induces angiogenesis in vitro. J Orthop Res, 2011;29:523-530.
50. Moraes C, Sun Y, Simmons CA. Microfabricated platforms for mechanically dynamic cell culture. J Visualized Experiments, 2010; http://www.jove.com/index/Details.stp?ID=2224, doi:10.3791/2224.
49. Rask F*, Mihic A*, Reis L, Dallabrida SM, Ismail NS, Sider KL, Simmons CA, Rupnick MA, Weisel RD, Li R, Radisic M. Hydrogels modified with QHREDGS peptide support cardiomyocyte survival in vitro and after sub-cutaneous implantation. Soft Matter, 2010;95:105-117.
48. Sharifpoor S, Simmons CA, Labow RS, Santerre JP. A study of vascular smooth muscle cell function under cyclic mechanical loading in a degradable polyurethane scaffold with optimized porosity. Acta Biomaterialia, 2010;6:4218-4228.
47. Moraes C, Wyss K, Brisson E, Keith BA, Sun Y, Simmons CA. An undergraduate lab (on-a-chip): Probing single cell mechanics on a microfluidic platform. Cellular and Molecular Bioengineering, 2010;3:319-330.
46. Yuen A, Laschinger C, Talior I, Lee W, Chan M, Birek J, Young EWK, Sivagurunathan K, Won E, Simmons CA, McCulloch CA. Methylglyoxal-modified collagen promotes myofibroblast differentiation. Matrix Biology, 2010;29:537-48.
45. Eilaghi A, Flanagan JG, Tertinegg I, Simmons CA, Brodland GW, Ethier CR. Biaxial mechanical testing of human sclera. J Biomech, 2010;43:1696-1701.
44. Fiddes LK, Raz N, Srigunapalan S, Tumarkan E, Parkharenko V, Simmons CA, Wheeler AR, Kumacheva E. A circular cross-section PDMS microfluidics system for replication of cardiovascular flow conditions. Biomaterials, 2010;31:3459-3464.
43. Eilaghi A, Flanagan JG, Simmons CA, Ethier CR. Effects of scleral stiffness properties on optic nerve head biomechanics. Ann Biomed Eng, 2010;38:1586-1592.
42. Moraes C, Sun Y, Simmons CA. Chips & Tips: Connector-less manipulation of small liquid volumes in microchannels. www.rsc.org/Publishing/Journals/lc/microchannels.asp, Lab Chip, June 11, 2010.
41. Young EWK, Watson ML, Srigunapalan S, Wheeler AR, Simmons CA. Technique for real-time measurements of endothelial permeability in a microfluidic membrane chip using laser-induced fluorescence detection. Anal Chem, 2010;82:808-816.
40. Bhana B, Iyer RK, Chen WL, Zhao R, Sider KL, Likhitpanichkul M, Simmons CA, Radisic M. Influence of substrate stiffness on the phenotype of heart cells. Biotechnol Bioeng, 2010;105:1148-1160. Journal cover
39. Chen WLK, Likhitpanichkul M, Ho A, Simmons CA. Integration of statistical modeling and high-content microscopy to systematically investigate cell-substrate interactions. Biomaterials, 2010;31:2489-2497.
38. Moraes C, Chen J-H, Sun Y, Simmons CA. Microfabricated arrays for high-throughput screening of cellular response to cyclic substrate deformation. LabChip, 2010;10:227-234.
37. Young EWK, Simmons CA. Macro- and microscale fluid flow systems for endothelial cell biology. LabChip, 2010;10:143-160. Journal cover
36. Moraes C, Wang GH, Sun Y, Simmons CA. A microfabricated platform for high-throughput unconfined compression of micropatterned biomaterial arrays. Biomaterials, 2010;31:577-584.
35. Chen JH, Liu C, You L, Simmons CA. Boning up on Wolff's Law: Mechanical regulation of the cells that make and maintain bone. J Biomech, 2010;43:108-118.
34. Fiddes L, Chan HK, Wyss K, Simmons CA, Kumacheva E, Wheeler AR. Augmenting microgel flow via receptor-ligand binding in the constrained geometries of microchannels. Lab Chip, 2009;9:286-290.
33. Zhao R, Wyss K, Simmons CA. Comparison of analytical and inverse finite element approaches to estimate cell viscoelastic properties by micropipette aspiration. J Biomech, 2009;42:2768-2773. Supplemental material
32. Young EWK, Simmons CA. “Student lab”-on-a-chip: Integrating low-cost microfluidics into undergraduate teaching labs to study multiphase flow phenomena in small vessels. Chem Eng Educ, 2009;43:232-240.
31. Moraes C, Kagoma YK, Beca BM, Tonelli-Zasarsky RLM, Sun Y, Simmons CA. Integrating polyurethane culture substrates into multilayer poly(dimethylsiloxane) microdevices. Biomaterials, 2009;30:5241-5250.
30. Simmons CA. Aortic valve mechanics: an emerging role for the endothelium. J Am Coll Cardiol, 2009;53:1456-1458.
29. Moraes C, Sun Y, Simmons CA. Solving the shrinkage-induced PDMS alignment registration issue in multilayer soft lithography. J Micromech Microeng, 2009;19:065015. iopscience_express_60.jpg
28. Yip CY, Chen JH, Zhao R, Simmons CA. Calcification by valve interstitial cells is regulated by the stiffness of the extracellular matrix. Arterioscler Thromb Vasc Biol, 2009;29:936-942. Supplemental material
27. Chen JH, Yip CY, Sone ED, Simmons CA. Identification and characterization of aortic valve mesenchymal progenitor cells with robust osteogenic calcification potential. Am J Pathology, 2009;174:1109-1119.
26. Brooks PJ, Nilforoushan D, Manolson MF, Simmons CA, Gong S-G. Molecular markers of early orthodontic tooth movement. Angle Orthod, 2009; 79:1108-1113.
25. Cheung WY*, Young EWK*, Simmons CA. Techniques for isolating and purifying porcine aortic valve endothelial cells. J Heart Valve Dis, 2008;17:674-681.
24. Pho M, Lee W, Watt DR, Laschinger C, Simmons CA, McCulloch CA. Cofilin is a marker of myofibroblast differentiation in cells from porcine aortic cardiac valves. Am J Physiol Heart Circ, 2008;294:H1767-1778.
23. Spiteri C, Young EWK, Simmons CA, Pilliar RM, Kandel RA. Substrate architecture and fluid-induced shear stress during chondrocyte seeding: Role of α5β1 integrin. Biomaterials, 2008; 29:2477-2489.
22. Tong J, Simmons CA, Sun Y. Precision patterning of PDMS membranes and applications. Journal Micromech Microeng, 2008;18:037004 (5 pp). iopscience_express_60.jpg
21. Li W, Young EWK, Seo M, Nie Z, Garstecki P, Simmons CA, Kumacheva, E. Simultaneous microfluidic generation of droplets with different dimensions. Soft Matter, 2008;4:258-262.
20. Butcher JT, Simmons CA, Warnock JN. Mechanobiology of the aortic heart valve. J Heart Valve Dis, 2008;17:62-73.
19. Young EWK, Wheeler AR, Simmons CA. Matrix-dependent adhesion of vascular and valvular endothelial cells in microfluidic channels. Lab Chip, 2007;7:1759-1766.
18. Chong SA, Lee W, Arora PD, Laschinger C, Young EWK, Simmons CA, Manolson M, Sodek J, McCulloch CA. Methylglyoxal inhibits the binding step of collagen phagocytosis. J Biol Chem, 2007; 282:8510-8520.
17. Moraes C, Simmons CA, Sun Y. Cell mechanics meets MEMS. CSME Bulletin, Fall 2006. N/A
16. Young EWK, Wheeler AR, Simmons CA. Avoiding bubble injection by droplet merging. Chips & Tips (online supplement to Lab on a Chip), Oct. 23, 2006.
15. Simmons CA, Grant GR, Manduchi E, Davies PF. Spatial heterogeneity of endothelial phenotypes correlates with side-dependent vulnerability to calcification in normal porcine aortic valves. Circ Res, 2005;96:792-799. Supplemental data / Supplemental material
14. Huang YC, Simmons CA, Kaigler D, Rice KG, Mooney DJ. Bone regeneration in a rat cranial defect with delivery of PEI-condensed plasmid DNA encoding for bone morphogenetic protein-4 (BMP-4). Gene Ther, 2005;12:418-426.
13. Murphy WL, Hsiong S, Richardson TP, Simmons CA, Mooney DJ. Effects of a bone-like mineral film on phenotype of adult human mesenchymal stem cells in vitro. Biomaterials, 2005; 26:303-310.
12. Simmons CA, Zilberberg J, Davies PF. A rapid, reliable method to isolate high quality endothelial RNA from small spatially-defined locations. Ann Biomed Eng, 2004;32:1453-1459.
11. Simmons CA, Nikolovski J, Thornton AJ, Matlis S, Mooney DJ. Mechanical stimulation and mitogen-activated protein kinase signaling independently regulate osteogenic differentiation and mineralization by calcifying vascular cells. J Biomech, 2004;37:1531-1541.
10. Davies PF, Passerini AG, Simmons CA. Aortic valve: turning over a new leaf(let) in endothelial phenotypic heterogeneity. Arterioscler Thromb Vasc Biol, 2004;24:1331-1333.
9. Simmons CA, Alsberg E, Hsiong S, Kim WJ, Mooney DJ. Dual growth factor delivery and controlled scaffold degradation enhance in vivo bone formation by transplanted bone marrow stromal cells. Bone, 2004;35:562-569.
8. Murphy WL*, Simmons CA*, Kaigler D, Mooney DJ. Bone regeneration via a mineral substrate and induced angiogenesis. J Dent Res, 2004;83:204-210.
7. Simmons CA, Matlis S, Thornton AJ, Chen S, Wang CY, Mooney DJ. Cyclic strain enhances matrix mineralization by adult human mesenchymal stem cells via the extracellular signal-regulated kinase (ERK1/2) signaling pathway. J Biomech, 2003;36:1087-1096.
6. Simmons CA, Meguid SA, Pilliar RM. Mechanical regulation of localized and appositional bone formation around bone-interfacing implants. J Biomed Mater Res, 2001;55:63-71.
5. Simmons CA, Meguid SA, Pilliar RM. Differences in osseointegration rate due to implant surface geometry can be explained by local tissue strains. J Orthop Res, 2001;19:187-194.
4. Simmons CA, Valiquette N, Pilliar RM. Osseointegration of sintered porous-surfaced and plasma spray-coated implants: An animal model study of early postimplantation healing response and mechanical stability. J Biomed Mater Res, 1999;47:127-138.
3. Simmons CA, Hipp JA. Method-based differences in the automated analysis of the three-dimensional morphology of trabecular bone. J Bone Miner Res, 1997;12:942-947.
2. Hipp JA, Jansujwicz A, Simmons CA, Snyder BD. Trabecular bone morphology from micro-magnetic resonance imaging. J Bone Miner Res, 1996;11:286-297.
1. Elke RP, Cheal EJ, Simmons C, Poss R. Three-dimensional anatomy of the cancellous structures within the proximal femur from computed tomography data. J Orthop Res, 1995;13:513-523.

*: Equal contributors
#: Co-corresponding authors




2014/06/05 21:08, Richard Tam